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Advances in the T7 phage display system

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成果类型:
期刊论文
作者:
Deng, Xiangying;Wang, Li;You, Xiaolong;Dai, Pei;Zeng, Yanhua*
通讯作者:
Zeng, Yanhua
作者机构:
[Dai, Pei; Wang, Li; Deng, Xiangying; Zeng, Yanhua; You, Xiaolong] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hunan Prov Key Lab Special Pathogens Prevent & Co, Inst Pathogen Biol,Med Coll, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
[Deng, Xiangying] Cent S Univ, Canc Res Inst, Key Lab Carcinogenesis & Canc Invas, Chinese Minist Educ, Changsha 410078, Hunan, Peoples R China.
通讯机构:
[Zeng, Yanhua] U
Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hunan Prov Key Lab Special Pathogens Prevent & Co, Inst Pathogen Biol,Med Coll, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
T7 phage;T7 phage display;protein interaction;antigen discovery;vaccine development;cancer diagnosis and treatment
期刊:
MOLECULAR MEDICINE REPORTS
ISSN:
1791-2997
年:
2018
卷:
17
期:
1
页码:
714-720
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31370207]; Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control [2014-5]; Construct Program of the Key Discipline in Hunan Province [2011-75]; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [2015-351]
机构署名:
本校为第一且通讯机构
院系归属:
医学院
药学与生物科学学院
摘要:
The present review describes the advantages and updated applications of the T7 phage display system in bioscience and medical science. Current phage display systems are based on various bacteriophage vectors, including M13, T7, T4 and f1. Of these, the M13 phage display is the most frequently used, however, the present review highlights the advantages of the T7 system. As a phage display platform, M13 contains single-stranded DNA, while the T7 phage consists of double-stranded DNA, which exhibits increased stability and is less prone to mutation during replication. Additional characteristics o...

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