FTH1 indicates poor prognosis and promotes metastasis in head and neck squamous cell carcinoma

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liao, Qingyun;Yang, Jing;Lu, Zhaoyi;Jiang, Qingshan;Gong, Yongqian;...

通讯作者：

Liu, ZF

作者机构：

[Peng, Hong; Liu, Zhifeng; Gong, Yongqian; Jiang, Qingshan; Liu, Lijun; Liao, Qingyun; Wang, Qin] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Otolaryngol, Hengyang, Hunan, Peoples R China.

[Yang, Jing] Univ South China, Canc Res Inst, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Hengyang, Hunan, Peoples R China.

[Yang, Jing] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Gastroenterol, Hengyang, Hunan, Peoples R China.

[Zhang, Xin; Lu, Zhaoyi] Cent South Univ, Key Lab Hunan Prov, Otolaryngol Major Dis Res, Changsha, Hunan, Peoples R China.

通讯机构：

[Liu, ZF ] U

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Otolaryngol, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

Biomarker;FTH1 (ferritin heavy chain);HNSCC (head and neck squamous cell carcinoma);Metastasis;Prognosis

期刊：

PEERJ

ISSN：

2167-8359

年：

2023

卷：

页码：

e16493

DOI：

10.7717/peerj.16493

基金类别：

Hunan provincial Health and Family Planning Commission [B202307019501, 202103030223, 20201947, B20180186]; Hunan Provincial Natural Science Foundation of China [2021JJ40502, 2019JJ50547]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

BACKGROUND: Currently, ferritin heavy chain (FTH1) has been increasingly found to play a crucial role in cancer as a core regulator of ferroptosis, while its role of non-ferroptosis in head and neck squamous cell carcinoma (HNSCC) is still unclear. METHODS: Herein, we analyzed the expression level of FTH1 in HNSCC using TCGA database, and FTH1 protein in HNSCC tissues and cell lines was determined by immunohistochemistry (IHC) and western blotting, respectively. Then, its prognostic value and relationship with clinical parameters were investigated in HNSCC patients. Additionally, the biologica...

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FTH1 indicates poor prognosis and promotes metastasis in head and neck squamous cell carcinoma

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