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MicroRNA-7a ameliorates neuropathic pain in a rat model of spinal nerve ligation via the neurofilament light polypeptide-dependent signal transducer and activator of transcription signaling pathway

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成果类型:
期刊论文
作者:
Yang, Feng-Rui;Chen, Ji;Yi, Han;Peng, Liang-Yu;Hu, Xiao-Ling;...
通讯作者:
Guo, Qu-Lian
作者机构:
[Yang, Feng-Rui; Guo, Qu-Lian] Cent S Univ, Xiangya Hosp, Dept Anesthesiol, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.
[Yang, Feng-Rui; Yi, Han; Peng, Liang-Yu; Hu, Xiao-Ling] Univ South China, Affiliated Hosp 1, Dept Anesthesiol, Hengyang, Peoples R China.
[Chen, Ji] Univ South China, Affiliated Hosp 1, Dept Endocrinol, Hengyang, Peoples R China.
通讯机构:
[Guo, Qu-Lian] C
Cent S Univ, Xiangya Hosp, Dept Anesthesiol, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.
语种:
英文
关键词:
Neuropathic pain;microRNA-7a;neurofilament light polypeptide;signal transducer and activator of transcription signaling pathway
期刊:
Molecular Pain
ISSN:
1744-8069
年:
2019
卷:
15
页码:
1744806919842464
基金类别:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by National Natural Science Foundation of China (No. 81300971), Natural Science Foundation of Hunan Province (No. 2016JJ4079), and Foundation of Hunan Provincial Health and Family Planning Commission (No. B2016129).
机构署名:
本校为其他机构
院系归属:
医学院
摘要:
Neuropathic pain is a type of chronic pain induced by either central or peripheral nerve injury. MicroRNAs have been recently linked to many diseases, including neuropathic pain. However, the role of miR-7a in neuropathic pain still remains elusive. Thus, we aim to investigate the effects of miR-7a on neuropathic pain based on the spinal nerve ligation rat model. After establishment of spinal nerve ligation rat models, rats were infected with adeno-associated virus-neurofilament light polypeptide, adeno-associated virus-miR-7a or treated with m...

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