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Mycoplasma pneumoniae MPN606 induces inflammation by activating MAPK and NF-κB signaling pathways

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成果类型:
期刊论文
作者:
Zhang, Ru;Zuo, Yingying;Li, Shuihong
通讯作者:
Li, SH
作者机构:
[Li, Shuihong; Zhang, Ru; Zuo, Yingying] Univ South China, Inst Pathogen Biol, Hengyang Med Coll, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Li, SH ] U
Univ South China, Inst Pathogen Biol, Hengyang Med Coll, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
M. pneumoniae;MAPK;NF-κB;RAW264.7;rMPN606
期刊:
Microbial Pathogenesis
ISSN:
0882-4010
年:
2025
卷:
200
页码:
107288
基金类别:
CRediT authorship contribution statement Ru Zhang: Writing – review & editing, Writing – original draft, Project administration, Methodology, Formal analysis. Yingying Zuo: Writing – review & editing, Writing – original draft. Shuihong Li: Writing – review & editing, Validation, Supervision, Resources, Project administration, acquisition. The authors are supported by the Scientific Research Fund of Hunan Provincial Education Department , China (Grant No. 21A0269 ).
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Mycoplasma pneumoniae ( M. pneumoniae ) is one of the major pathogens causing community-acquired pneumonia (CAP), and its pathogenic mechanism is not fully understood. Inflammatory response is the most basic and common pathological phenomenon of CAP, but the specific mechanism needs further investigation. In this study, the inflammatory action of M. pneumoniae MPN606 protein was confirmed and its molecular mechanism was tentatively investigated. Compared with the control group treated with PBS, stimulation of RAW264.7 cells with rMPN606 can pro...

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