Mycoplasma pneumoniae downregulates RECK to promote matrix metalloproteinase-9 secretion by bronchial epithelial cells

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成果类型：

期刊论文

作者：

Qin, Lianmei;Liu, Lu;Wu, Yueping;Chen, Yiwen;Wu, Yueyue;...

通讯作者：

Xiaoxing You

作者机构：

[Wu, Yueyue; Chen, Liesong; Zhu, Cuiming; You, Xiaoxing; Zeng, Yanhua; Xi, Yixuan; Qin, Lianmei; Chen, Yiwen; Xiu, Feichen; Liu, Lu] Univ South China, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang Med Sch,Inst Pathogen Biol, Hengyang, Peoples R China.

[Wu, Yueping; Qin, Lianmei] Shenzhen Childrens Hosp, Dept Blood Transfus, Shenzhen, Peoples R China.

[Luo, Haodang; He, Jun] Univ South China, Hengyang Med Sch, Affiliated Nanhua Hosp, Dept Clin Lab, Hengyang, Peoples R China.

[Hu, Jun] Univ South China, Hengyang Med Sch, Affiliated Hosp 2, Dept Cardiothorac Surg, Hengyang, Peoples R China.

[Wu, Ning] Hengyang 1 Peoples Hosp, Dept Clin Lab, Hengyang, Peoples R China.

通讯机构：

[Xiaoxing You] I

Institute of Pathogenic Biology, Hengyang Medical School, Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, China

语种：

英文

关键词：

Mycoplasma pneumoniae;matrix metalloproteinase-9;reversion-inducing cysteine-rich protein with Kazal motifs (RECK);bronchial epithelial cell

期刊：

Virulence

ISSN：

2150-5594

年：

2022

卷：

期：

页码：

1270-1284

DOI：

10.1080/21505594.2022.2101746

基金类别：

This work was supported by the National Natural Science Foundation of China [grant no. 31670177], Scientific Research Project of Hunan Provincial Health Committee [grant no. 20201915] and the Science and Technology Program of Hengyang [grant no. 2020jh042917, 202010021604].

机构署名：

本校为第一机构

院系归属：

医学院

药学与生物科学学院

摘要：

Airway epithelial cells function as both a physical barrier against harmful substances and pathogenic microorganisms and as an important participant in the innate immune system. Matrix metalloproteinase-9 (MMP-9) plays a crucial role in modulating inflammatory responses during respiratory infections. However, the signalling cascade that induces MMP-9 secretion from epithelial cells infected with Mycoplasma pneumoniae remains poorly understood. In this study, we investigated the mechanism of MMP-9 secretion in airway epithelial cells infected wi...

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Mycoplasma pneumoniae downregulates RECK to promote matrix metalloproteinase-9 secretion by bronchial epithelial cells

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