Mycoplasma pneumoniae lipids license TLR-4 for activation of NLRP3 inflammasome and autophagy to evoke a proinflammatory response

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Luo, H.;He, J.;Qin, L.;Chen, Y.;Chen, L.;...

通讯作者：

You, X.;Wu, Y.

作者机构：

[You, X.; Luo, H.; Li, R.; Qin, L.; Chen, Y.; Chen, L.; You, X; Wu, Y.; Zhu, C.; Zeng, Y.] Univ South China, Inst Pathogen Biol, Hengyang Med Coll,Hunan Prov Cooperat Innovat Ctr, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang 421001, Peoples R China.

[Luo, H.; He, J.] Univ South China, Affiliated Nanhua Hosp, Dept Clin Lab, Hengyang, Peoples R China.

通讯机构：

[You, X; Wu, Y] U

Univ South China, Inst Pathogen Biol, Hengyang Med Coll,Hunan Prov Cooperat Innovat Ctr, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

autophagy;lipid;Mycoplasma pneumonia;NF-κB;NLRP3;Toll-like receptor 4

期刊：

Clinical and Experimental Immunology

ISSN：

0009-9104

年：

2021

卷：

203

期：

页码：

66-79

DOI：

10.1111/cei.13510

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31670177, 31970177]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2019JJ40253]; Construct Program of the 'Double First-Class discipline' of University of South China [2019SYL]; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [2015-351]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Mycoplasma pneumoniae is an obligate pathogen that causes pneumonia, tracheobronchitis, pharyngitis and asthma in humans. It is well recognized that membrane lipoproteins are immunostimulants exerting as lipopolysaccharides (LPS) and play a crucial role in the pathogenesis of inflammatory responses upon M. pneumoniae infection. Here, we report that the M. pneumoniae-derived lipids are another proinflammatory agents. Using an antibody-neutralizing assay, RNA interference or specific inhibitors, we found that Toll-like receptor 4 (TLR-4) is essen...

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Mycoplasma pneumoniae lipids license TLR-4 for activation of NLRP3 inflammasome and autophagy to evoke a proinflammatory response

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