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A RBC membrane-camouflaged biomimetic nanoplatform for enhanced chemo-photothermal therapy of cervical cancer

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成果类型:
期刊论文
作者:
Luo, Lin;Zeng, Furen;Xie, Jiangbo;Fan, Jialong;Xiao, Shengying;...
通讯作者:
Xie, Hailong;Liu, Bin
作者机构:
[Xie, Hailong; Luo, Lin] Univ South China, Sch Med, Inst Canc Res, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Hengyang 421001, Hunan, Peoples R China.
[Xiao, Shengying; Zeng, Furen] Hunan Prov Peoples Hosp, Oncol Dept 2, Changsha 410082, Hunan, Peoples R China.
[Xie, Jiangbo] Cent South Univ, Xiangya Sch Med, Affiliated Canc Hosp, Hunan Canc Hosp, Changsha 410013, Hunan, Peoples R China.
[Liu, Bin; Fan, Jialong; Wang, Zhou] Hunan Univ, Coll Biol, Changsha 410082, Hunan, Peoples R China.
通讯机构:
[Xie, Hailong] U
[Liu, Bin] H
Univ South China, Sch Med, Inst Canc Res, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Hengyang 421001, Hunan, Peoples R China.
Hunan Univ, Coll Biol, Changsha 410082, Hunan, Peoples R China.
语种:
英文
关键词:
Biomimetics;Blood;Chemotherapy;Controlled drug delivery;Cytology;Diseases;Drug interactions;Graphene;Lanthanum compounds;Mammals;Photosensitizers;Semiconductor quantum dots;Tumors;Biochemical parameters;Blood circulation;Cervical cancers;Drug transportations;Indocyanine Green;Photothermal therapy;Strong interaction;Targeted delivery systems;Targeted drug delivery;antineoplastic antibiotic;biomimetic material;doxorubicin;nanoparticle;photosensitizing agent;animal;apoptosis;Bagg albino mouse;cell proliferation;cell survival;chemistry;diagnostic imaging;drug effect;erythrocyte membrane;experimental neoplasm;female;fluorescence imaging;HeLa cell line;human;mouse;particle size;photochemotherapy;surface property;uterine cervix tumor;Animals;Antibiotics, Antineoplastic;Apoptosis;Biomimetic Materials;Cell Proliferation;Cell Survival;Doxorubicin;Erythrocyte Membrane;Female;HeLa Cells;Humans;Mice;Mice, Inbred BALB C;Nanoparticles;Neoplasms, Experimental;Optical Imaging;Particle Size;Photochemotherapy;Photosensitizing Agents;Surface Properties;Uterine Cervical Neoplasms
期刊:
JOURNAL OF MATERIALS CHEMISTRY B
ISSN:
2050-750X
年:
2020
卷:
8
期:
18
页码:
4080-4092
基金类别:
This work was supported by the Natural Science Foundation of Hunan Province (No. 2018JJ2338 and 2019JJ80022), the Construction Program of the Key Discipline in Hunan Province, P. R. China (Basic Medicine Sciences in the University of South China), the Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, and the Hunan Province Co-Education Department document (Approval number: 2014-405e).
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Due to the untargeted release of chemical drugs, the efficacy of chemotherapy is often compromised along with serious side effects on patients. Recently, the development of targeted delivery systems using nanomaterials as carriers has provided more alternatives for chemical drug transportation. In this study, we developed a novel targeted nanocomplex of GOQD-ICG-DOX@RBCM-FA NPs (GID@RF NPs). First, PEG modified graphene oxide quantum dots (GOQDs) were used to co-load the photosensitizer of indocyanine green (ICG) and DOX, to form GOQD-ICG-DOX N...

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