Synthesis and antitumor study of novel porphyrin–coumarin derivatives for chemotherapy and photodynamic therapy

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成果类型：

期刊论文

作者：

Tian, Zejie;Shi, Lei;Liu, Zhenhua;Li, Hui;Yang, Lingyan;...

通讯作者：

Liu, YM

作者机构：

[Liu, Yunmei; Yang, Lingyan; Li, Hui; Shi, Lei; Liu, Zhenhua; Tian, Zejie] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang 421001, Hunan, Peoples R China.

[Liu, Yunmei; Yang, Lingyan; Li, Hui; Shi, Lei; Liu, Zhenhua; Tian, Zejie] Hunan Prov Key Lab Tumor Microenvironm Respons Dru, Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Liu, Yunmei; Liu, YM] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Liu, YM ] U

Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Photodynamic therapy;Porphyrin;Coumarin;Chemotherapy

期刊：

Journal of Molecular Structure

ISSN：

0022-2860

年：

2023

卷：

1288

页码：

135826

DOI：

10.1016/j.molstruc.2023.135826

基金类别：

The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Photodynamic therapy (PDT) is attractive in cancer treatment because of its non-invasive and low side effects. In this study, we synthesized 20 porphyrin-coumarin compounds via condensation reactions of porphyrins with coumarin derivatives. In the singlet oxygen (1O2) assay, DPBF fluorescence was quenched by 85% after 10 s of light irradiation; the fluorescence of DPBF almost disappeared at 30 s by light irradiation. This indicates that the porphyrin-coumarin compounds have excellent 1O2 generation efficiency. Moreover, porphyrin-coumarin compounds showed different inhibitory effects on A549 a...

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Synthesis and antitumor study of novel porphyrin–coumarin derivatives for chemotherapy and photodynamic therapy

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