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The Preparation of Novel P(OEGMA-co-MEO2MA) Microgels-Based Thermosensitive Hydrogel and Its Application in Three-Dimensional Cell Scaffold

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成果类型:
期刊论文
作者:
Liu, Yang;Luo, Yu-Ning;Zhang, Pei;Yang, Wen-Fei;Zhang, Cai-Yao;...
通讯作者:
Yang Liu
作者机构:
[Zhang, Cai-Yao; Yin, Yu-Li; Zhang, Pei; Liu, Yang; Yang, Wen-Fei; Luo, Yu-Ning] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Sch Pharm, Hengyang Med Sch,Hunan Prov Key Lab Tumor Microen, Hengyang 421001, Peoples R China.
通讯机构:
[Liu, Y.] H
Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmacy, Hengyang Medical School, University of South China, Hengyang, China
语种:
英文
关键词:
3D culture;P(OEGMA-co-MEO2MA);hydrogel;microgel;scaffold;thermosensitive
期刊:
Gels
ISSN:
2310-2861
年:
2022
卷:
8
期:
5
页码:
313-
基金类别:
Conceptualization, Y.L.; methodology, Y.-N.L., P.Z., W.-F.Y., C.-Y.Z. and Y.-L.Y.; validation, Y.L., Y.-N.L. and Y.-L.Y.; formal analysis, Y.-N.L., P.Z., W.-F.Y., C.-Y.Z. and Y.-L.Y.; investigation, P.Z., W.-F.Y. and C.-Y.Z.; resources, Y.L.; writing—original draft preparation, Y.-N.L., P.Z., W.-F.Y., C.-Y.Z. and Y.-L.Y.; writing—review and editing, Y.L., Y.-N.L. and Y.-L.Y.; visualization, Y.-N.L., P.Z., W.-F.Y., C.-Y.Z. and Y.-L.Y.; supervision, Y.L.; project administration, Y.L.; funding acquisition, Y.L. All authors have read and agreed to the published version of the manuscript. This research was funded by the Natural Science Foundation of Hunan Province (No. 2021JJ30597), Scientific Research Projects of Health Commission of Hunan Province (No. 202113022002), and Hengyang Guided Science and Technology Project (No. 2020jh042809).
机构署名:
本校为第一机构
院系归属:
药学与生物科学学院
摘要:
Thermosensitive hydrogel scaffolds have attracted particular attention in three-dimensional (3D) cell culture. It is very necessary to develop a type of thermosensitive hydrogel material with low shrinkage, and excellent biocompatibility and biodegradability. Here, five types of thermosen-sitive microgels with different volume phase transition temperature (VPTT) or particle sizes were first synthesized using 2-methyl-2-propenoic acid-2-(2-methoxyethoxy) ethyl ester (MEO2 MA) and oligoethylene glycol methyl ether methacrylate (OEGMA) as thermose...

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