MicroRNA-467b targets LPL gene in RAW 264.7 macrophages and attenuates lipid accumulation and proinflammatory cytokine secretion

首页 > 成果 > 详情

认领

导出

下载 Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Tian, Guo-Ping;Chen, Wu-Jun;He, Ping-Ping;Tang, Shi-Lin;Zhao, Guo-Jun;...

通讯作者：

Yin, Wei-Dong

作者机构：

[Yin, Kai; He, Ping-Ping; Tian, Guo-Ping; Ouyang, Xin-Ping; Chen, Wu-Jun; Zhao, Guo-Jun; Lv, Yun-Cheng; Tang, Chao-Ke; Yin, Wei-Dong; Wang, Ping-Ping; Tang, Shi-Lin] Univ S China, Key Lab Atherosclerol Hunan Prov, Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.

[Huang, Su-Lan; Cheng, Hong; Chen, Yuan; Tian, Guo-Ping; Tang, Shi-Lin] Univ S China, Affiliated Hosp 2, Dept Cardiovasc Med, Hengyang 421001, Hunan, Peoples R China.

[Chen, Wu-Jun] Univ S China, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.

[Chen, Wu-Jun] Univ S China, Dept Diagnost, Hengyang 421001, Hunan, Peoples R China.

[Fu, Yuchang] Univ Alabama Birmingham, Dept Nutr Sci, Birmingham, AL 35294 USA.

通讯机构：

[Yin, Wei-Dong] U

Univ S China, Key Lab Atherosclerol Hunan Prov, Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Atherosclerosis;Lipid accumulation;LPL;MicroRNA-467b;Proinflammatory cytokine secretion

期刊：

Biochimie

ISSN：

0300-9084

年：

2012

卷：

期：

页码：

2749-2755

DOI：

10.1016/j.biochi.2012.08.018

基金类别：

The authors gratefully acknowledge the financial support from the National Natural Sciences Foundation of China ( 81270269 , 81070220 and 81170278 ), and Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions (2008-244) of Human Province, China.

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

LPL (lipoprotein lipase) is a rate-limiting enzyme involved in the hydrolysis of triglycerides. Previous studies have shown that microRNA (miR)-467b regulates hepatic LPL expression and plays a role in the progression of steatosis or abnormal lipid retention in obese mice. Macrophage-derived LPL has been shown to promote atherosclerosis. However, if miR-476b influences macrophage LPL expression and the subsequent effects are unknown. Here, we utilized oxLDL-treatment RAW 264.7 macrophages that were transfected with miR-467b mimics or inhibitors...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

MicroRNA-467b targets LPL gene in RAW 264.7 macrophages and attenuates lipid accumulation and proinflammatory cytokine secretion

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问