19F MRI-fluorescence imaging dual-modal cell tracking with partially fluorinated nanoemulsions

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成果类型：

期刊论文

作者：

Tang, Ting;Zhu, Qiang;Liu, Shuang;Dai, Hailong;Li, Yu;...

通讯作者：

Zheng, Zitong(nhzzt@163.com);Chen, ShiZhen(chenshizhen@apm.ac.cn);Jiang, Zhong-Xing(zxjiang@apm.ac.cn)

作者机构：

[Tang, Ting; Dai, Hailong; Chen, Kexin; Tang, Caihong; Zhu, Qiang; Zheng, Zitong] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Pharm,Hunan Prov Key Lab Tumor Microenvironm, Hengyang, Hunan, Peoples R China.

[Li, Yu; Tang, Ting; Jiang, Zhong-Xing; Zhou, Xin; Dai, Hailong; Chen, Kexin; Jiang, Mou; Zhu, Qiang; Zhu, Lijun; Chen, ShiZhen] Chinese Acad Sci, Wuhan Inst Phys & Math, Innovat Acad Precis Measurement Sci & Technol, Natl Ctr Magnet Resonance Wuhan,State Key Lab Magn, Wuhan, Peoples R China.

[Liu, Shuang] Changchun Univ Tradit Chinese Med, Affiliated Hosp, Dept Pediat, Changchun, Peoples R China.

通讯机构：

[Zheng, Z.] H

[Chen, S.; Jiang, Z.-X.] S

Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan, China

State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, China

语种：

英文

关键词：

19F MRI;fluorescence;Cell Tracking;partially fluorinated;Nanoemulsions

期刊：

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY

ISSN：

2296-4185

年：

2022

卷：

页码：

1049750

DOI：

10.3389/fbioe.2022.1049750

基金类别：

This work has received funding from the National Natural Science Foundation of China (22077098, 21921004, and 91859206), the Knowledge Innovation Program of Wuhan-Basic Research (2022020801010137), the National Key R&D Program of China (2018YFA0704000), the Laboratory of Tea and Health of Hengyang (202150083704), and the Undergraduate Research Learning and Innovative Experiment Project (S20221743071, S20221743277, and X202110555464).

机构署名：

本校为第一机构

院系归属：

药学与生物科学学院

摘要：

As a noninvasive 'hot-spot' imaging technology, fluorine-19 magnetic resonance imaging (19F MRI) has been extensively used in cell tracking. However, the peculiar physicochemical properties of perfluorocarbons (PFCs), the most commonly used 19F MRI agents, sometimes cause low sensitivity, poor cell uptake, and misleading results. In this study, a partially fluorinated agent, perfluoro-tert-butyl benzyl ether, was used to formulate a 19F MRI-fluorescence imaging (FLI) dual-modal nanoemulsion for cell tracking. Compared with PFCs, the partially f...

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19F MRI-fluorescence imaging dual-modal cell tracking with partially fluorinated nanoemulsions

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