Down-regulation of PCK2 inhibits the invasion and metastasis of laryngeal carcinoma cells

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Hu, Yun;Deng, Kun;Pan, Meihong;Liu, Shanyan;Li, Wenda;...

通讯作者：

Zuo, Jianhong

作者机构：

[Hu, Yun; Deng, Kun; Zuo, Jianhong; Huang, Jialu; Li, Wenda] Univ South China, Hengyang Med Sch, Canc Res Inst,Hunan Prov Key Lab Tumour Microenvi, Hunan Prov Key Lab Tumor Cellular & Mol Pathol,La, Hengyang 421002, Hunan, Peoples R China.

[Liu, Shanyan; Pan, Meihong; Zuo, Jianhong] Univ South China, Affiliated Nanhua Hosp, Hengyang 421002, Hunan, Peoples R China.

[Zuo, Jianhong; Yao, Jinwei] Univ South China, Affiliated Hosp 3, Hengyang 421900, Hunan, Peoples R China.

[Zuo, Jianhong] Univ South China, Hengyang Med Sch, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Zuo, Jianhong] U

Univ South China, Hengyang Med Sch, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Hypoxia;Invasion;Laryngeal cancer;Metastasis;PCK2

期刊：

AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH

ISSN：

1943-8141

年：

2020

卷：

期：

页码：

3842-3857

基金类别：

This study was supported by the National Natural Science Foundation of China (no. 81272960), the Key Research Program from the Science and Technology Department of Hunan Province, China (no. 2017SK2082) and the Key Research Program from the Science and Technology Department of Ningxia Hui Autonomous Region, China (no. 2019BFH-02012), the Key Research Program of Hunan Health Committee (20201909) and the program of Hengyang science and Technology Bureau (2017-1, 2020-67).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Laryngeal carcinoma is one of the common malignancies of head and neck. However, the pathogenesis of laryngeal cancer has been not completely clear. To identify the effects of hypoxia on the invasion, metastasis, and metabolism of laryngeal carcinoma, iTRAQ-labeling-with-LC-MS/MS analysis was performed to identify differentially expressed proteins of the SCC10A cells under hypoxia and normoxia, while metabolites were examined by metabolic profiling. 155 proteins and 180 metabolites were identified and the PCK2 protein was selected for validatio...

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Down-regulation of PCK2 inhibits the invasion and metastasis of laryngeal carcinoma cells

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