期刊论文

Tang, Chao-ke

英文

Biochemical and Biophysical Research Communications

0006-291X

2014

452

4

881-887

10.1016/j.bbrc.2014.08.120

The research is supported by the National Natural Sciences Foundation of China ( 81370377 , 81270269 , 81070220 , 81300158 and 81170278 ), Medical Scientific Research Projects of Hunan Province ( B2013-040 ), Science and Technology Project of Hunan Province ( 2014SK3088 ), Aid Program for Science and Technology Department of Human Province ( 2013FJ3027 ), Outstanding Young Aid Program for Education Department of Human Province ( 13B103 ), and Aid Program for Science and Technology Bureau of Hengyang City ( 2013KS20 , 2013KS25 ). Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions (2008-244) of Hunan Province, and the construct program of the key discipline in Hunan Province, China ( Basic Medicine Sciences in University of South China , Xiangjiaofa No. [2011] 76).

本校为第一且通讯机构

The purpose of this study is to determine whether IL-27 regulates macrophage ABCA1 expression, foam cell formation, and also explore the underlying mechanisms. Here, we revealed that IL-27 decreased lipid accumulation in THP-1 derived macrophages through markedly enhancing cholesterol efflux and increasing ABCA1 expression at both protein and mRNA levels. Our study further demonstrated that IL-27 increased ABCA1 level via activation of signal transducer and activator of transcription 3 (STAT3). Inhibition of Janus kinase 2, (JAK2)/STAT3 suppres...