Ferritin-mediated mitochondrial iron homeostasis is essential for the survival of hematopoietic stem cells and leukemic stem cells

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yi, Weiwei;Zhang, Jinhua;Huang, Yingxin;Zhan, Qiang;Zou, Mi;...

通讯作者：

Guo, J;Ju, Zhenyu;Chen, ZY

作者机构：

[Yi, Weiwei; Zhang, Jinhua; Guo, J; Guo, Jun] Jinan Univ, Dept Cardiol, Affiliated Hosp 1, Guangzhou 510630, Guangdong, Peoples R China.

[Chen, Zhiyang; Ju, Zhenyu; Yi, Weiwei; Zou, Mi; Huang, Yingxin; Zhan, Qiang; Ju, ZY; Chen, ZY] Jinan Univ, Inst Aging & Regenerat Med, Coll Life Sci & Technol, Key Lab Regenerat Med,Minist Educ, Guangzhou 510632, Guangdong, Peoples R China.

[Cheng, Xiang] Childrens Hosp, Capital Inst Pediat, Dept Hematol, Beijing 100020, Peoples R China.

[Zhang, Xuguang] Mengniu Inst Nutr Sci, Global R&D Innovat Ctr, Shanghai, Peoples R China.

[Zhang, Xuguang] Shanghai Inst Nutr & Hlth, Chinese Acad Sci, Shanghai, Peoples R China.

通讯机构：

[Ju, ZY; Chen, ZY ; Guo, J ] J

Jinan Univ, Dept Cardiol, Affiliated Hosp 1, Guangzhou 510630, Guangdong, Peoples R China.

Jinan Univ, Inst Aging & Regenerat Med, Coll Life Sci & Technol, Key Lab Regenerat Med,Minist Educ, Guangzhou 510632, Guangdong, Peoples R China.

语种：

英文

期刊：

Leukemia

ISSN：

0887-6924

年：

2024

卷：

期：

页码：

1003-1018

DOI：

10.1038/s41375-024-02169-y

基金类别：

National Natural Science Foundation of China (National Science Foundation of China) [92049112, 81901403, 32300663, 82230047]; National Natural Science Foundation of China [2021YFA1100103]; National Basic Research Program of China [2023KCXTD004]; Innovation Team Project of Universities in Guangdong Province [20204BCJ22027]; Jiangxi Provincial Natural Science Foundation

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

Iron metabolism plays a crucial role in cell viability, but its relationship with adult stem cells and cancer stem cells is not fully understood. The ferritin complex, responsible for intracellular iron storage, is important in this process. We report that conditional deletion of ferritin heavy chain 1 (Fth1) in the hematopoietic system reduced the number and repopulation capacity of hematopoietic stem cells (HSCs). These effects were associated with a decrease in cellular iron level, leading to impaired mitochondrial function and the initiation of apoptosis. Iron supplementation, antioxidant,...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Ferritin-mediated mitochondrial iron homeostasis is essential for the survival of hematopoietic stem cells and leukemic stem cells

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问