Chlamydia psittaci hypothetical inclusion membrane protein CPSIT_0842 evokes a pro-inflammatory response in monocytes via TLR2/TLR4 signaling pathways

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成果类型：

期刊论文

作者：

Xiao, Jian;He, Jun;He, Zhangping;Wang, Chuan;Li, Yumeng;...

通讯作者：

Yimou Wu

作者机构：

[Wu, Yimou; Li, Yumeng; Chen, Yuqing; Yan, Xiaoliang; He, Zhangping; Wang, Chuan; Xiao, Jian; Sun, Zhenjie] Univ South China, Inst Pathogen Biol, Hengyang Med Coll, Hunan Prov Key Lab Special Pathogens Prevent & Con, Hengyang 421001, Hunan, Peoples R China.

[He, Jun; Liu, Jian; He, Zhangping; Xiao, Jian] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Lab Med, Hengyang 421001, Hunan, Peoples R China.

[Liang, Mingxing] Affiliated Huaihua Hosp, Dept Lab Med, Huaihua 418000, Hunan, Peoples R China.

[Wu, Yimou; Li, Yumeng; Chen, Yuqing; Yan, Xiaoliang; He, Zhangping; Wang, Chuan; Xiao, Jian; Sun, Zhenjie] Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang 421001, Hunan, Peoples R China.

[Wu, Yimou] Univ South China, Pathogen Biol Inst, Hengyang Med Coll, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Yimou Wu] I

Institute of Pathogenic Biology, Hengyang Medical College, University of South China

Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Hengyang, Hunan, 421001, China<&wdkj&>Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, Hunan, 421001, China

语种：

英文

关键词：

Chlamydia psittaci;Inclusion membrane protein;MAPK;NF-κB;TLR

期刊：

Veterinary Microbiology

ISSN：

0378-1135

年：

2023

卷：

280

页码：

109693

DOI：

10.1016/j.vetmic.2023.109693

基金类别：

National Natural Science Foundation of China [31872643, 31800162]; Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation [2014-5]; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [2015-351]; Science and technology plan projects of Hengyang [2020jh042926, 51-116]

机构署名：

本校为第一机构

院系归属：

医学院

摘要：

Chlamydia psittaci (C. psittaci) is an obligate intracellular pathogen that resides within a membrane-bound compartment known as the inclusion. Upon entering the host cell, Chlamydiae secrete numerous proteins to modify the inclusion membrane. Inclusion membrane (Inc) proteins are important pathogenic factors in Chlamydia and play crucial roles in the growth and development of Chlamydia. In the present study, the C. psittaci protein, CPSIT_0842, was identified and shown to localize to the inclusion membrane. Temporal analysis revealed that CPSI...

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Chlamydia psittaci hypothetical inclusion membrane protein CPSIT_0842 evokes a pro-inflammatory response in monocytes via TLR2/TLR4 signaling pathways

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