Involvement of calreticulin in cell proliferation, invasion and differentiation in diallyl disulfide-treated HL-60 cells

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yi, Lan;Shan, Jian;Chen, Xin;Li, Guoqing;Li, Linwei;...

通讯作者：

Su, Qi

作者机构：

[Yi, Lan; Li, Guoqing; Li, Linwei] Univ South China, Coll Pharm & Biol Sci, Hengyang 421001, Hunan, Peoples R China.

[Chen, Xin; Shan, Jian; Yi, Lan; Tan, Hui; Su, Qi] Univ South China, Canc Res Inst, 28 Changshengxi Rd, Hengyang 421001, Hunan, Peoples R China.

[Yi, Lan; Li, Guoqing] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Su, Qi] U

Univ South China, Canc Res Inst, 28 Changshengxi Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

calreticulin;CD11b antigen;CD33 antigen;diallyl disulfide;small interfering RNA;Article;cell culture;cell differentiation;cell invasion;cell proliferation;controlled study;flow cytometry;genetic transfection;HL 60 cell line;human;human cell;nitroblue tetrazolium test;protein expression;reverse transcription polymerase chain reaction;RNA interference;Western blotting

期刊：

ONCOLOGY LETTERS

ISSN：

1792-1074

年：

2016

卷：

期：

页码：

1861-1867

DOI：

10.3892/ol.2016.4850

基金类别：

The present study was sponsored by the National Natural Scientific Foundation of China (grant no. 81400117; Beijing, China), the Hunan Provincial Natural Science Foundation of China (grant no. 2015JJ4043; Changsha, China), China Postdoctoral Science Foundation (grant no. 2014M562115; Beijing, China) and the returned personnel Initial Funding of University of South China (grant no. 2014XQD46; Hengyang, China).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Diallyl disulfide (DADS) has shown potential as a therapeutic agent in various cancers. Previously, calreticulin (CRT) was found to be downregulated in differentiated HL‑60 cells treated with DADS. The present study investigated the role of CRT proteins in DADS‑induced proliferation, invasion and differentiation in HL‑60 cells. The present study demonstrated that DADS treatment significantly changed the morphology of HL‑60 cells and caused the significant time‑dependent downregulation of CRT. Small interfering RNA (siRNA)‑mediated knockdo...

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Involvement of calreticulin in cell proliferation, invasion and differentiation in diallyl disulfide-treated HL-60 cells

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