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CXCL13-neutralizing Antibody Alleviate Chronic Skeletal Muscle Degeneration in a Mouse Model.

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成果类型:
期刊论文
作者:
Xie, Zhongcheng;Yang, Jimin;Jiao, Chunmeng;Chen, Hui;Ouyang, Siyu;...
作者机构:
[Ouyang, Siyu; Liu, Zhiyang; Xie, Zhongcheng; Hou, Qin] Department of Anatomy, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China
[Yang, Jimin; Liu, Jifeng] Department of Otolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, 37 Guo Xue Lane, Chengdu 610064, Sichuan Province, China
[Jiao, Chunmeng] Department of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China
[Chen, Hui] Institute of Acupuncture Research, Institutes of Integrative Medicine, Fudan University, Shanghai 200032, China
语种:
英文
关键词:
CXCL13;FIBROBLAST.;Fibrosis;MUSCLE degeneration
期刊:
CURRENT MOLECULAR MEDICINE
ISSN:
1566-5240
年:
2024
机构署名:
本校为第一机构
院系归属:
医学院
摘要:
INTRODUCTION: Skeletal muscle degeneration is a common effect of chronic muscle injuries, including fibrosis and fatty infiltration, which is the replacement of preexisting parenchymal tissue by extracellular matrix proteins and abnormal invasive growth of fibroblasts and adipocytes. METHOD: This remodeling limits muscle function and strength, eventually leading to reduced quality of life for those affected. Chemokines play a major role in the regulation of immunocyte migration, inflammation, and tissue remodeling and are implicated in various fibrotic and degenerative diseases. In this study,...

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