The Relationship between Pharmacological Properties and Structure- Activity of Chrysin Derivatives

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成果类型：

期刊论文

作者：

Li, Yang;Li, Yan-peng;He, Jun*;Liu, Ding;Zhang, Qi-zhi;...

通讯作者：

He, Jun;Liu, Yunmei

作者机构：

[Liu, Yunmei; Li, Kang; Guo, Yu; Liu, Ding; Li, Yan-peng; Tang, Guo-Tao; Zhang, Qi-zhi; Li, Yang; Zheng, Xing] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

[He, Jun] Univ South China, Inst Chem & Chem Engn, Hengyang 421001, Peoples R China.

[He, J; Liu, YM] Univ South China, Inst Pharm & Pharmacol, 28 Changshcng West Rd, Hengyang 421001, Peoples R China.

通讯机构：

[He, J; Liu, YM] U

Univ South China, Inst Pharm & Pharmacol, 28 Changshcng West Rd, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

5 [(4 fluorobenzyl)oxy] 7 hydroxy 2 phenyl 4h chromen 4 one;7 o (ethoxycarbonyl)alkyl chrysin;7 o (ethoxycarbonyl)alkylamino chrysin;antiinfective agent;antivirus agent;chrysin;chrysin derivative;selenium;unclassified drug;antineoplastic agent;biological product;chrysin;flavonoid;antidiabetic activity;antineoplastic activity;antiviral activity;apoptosis;Article;cancer cell destruction;chemical modification;clinical outcome;drug mechanism;drug research;drug screening;drug structure;Enterovirus A71;G2 phase cell cycle checkpoint;gene therapy;human;inflammation;M phase cell cycle checkpoint;nonhuman;structure activity relation;animal;chemistry;drug development;drug effect;neoplasm;procedures;structure activity relation;Animals;Antineoplastic Agents;Apoptosis;Biological Products;Drug Discovery;Flavonoids;Humans;Neoplasms;Structure-Activity Relationship

期刊：

MINI-REVIEWS IN MEDICINAL CHEMISTRY

ISSN：

1389-5575

年：

2019

卷：

期：

页码：

555-568

DOI：

10.2174/1389557518666180424094821

基金类别：

We are grateful to the Construct Program of the Key Discipline in Hunan Province and Hunan Province Cooperative innovation center for molecular target new drug study [Hunan Provincial Education Department document (Approval number: 2014-405)] for financial support.

机构署名：

本校为第一且通讯机构

院系归属：

化学化工学院

药学与生物科学学院

摘要：

Chrysin is a natural product of a flavonoid compound. Chemically, chrysin consists of two phenyl rings (A and B) and a heterocyclic ring (C). Biologically, chrysin exerts many different physiological activities. In recent years, with the in-depth development for more active drugs, the synthesis and biological activities of chrysin derivatives have been well studied. Besides, structure-activity relationship of chrysin revealed that the chemical construction meets the critical chemical structural necessities of flavonoids for numerous pharmacolog...

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The Relationship between Pharmacological Properties and Structure- Activity of Chrysin Derivatives

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