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Recent Developments in Deaminative Functionalization of Alkyl Amines

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成果类型:
期刊论文
作者:
Li, Yi-Na;Xiao, Fang;Guo, Yu*;Zeng, Yao-Fu*
通讯作者:
Guo, Yu;Zeng, Yao-Fu
作者机构:
[Guo, Yu; Guo, Y; Zeng, Yao-Fu; Xiao, Fang; Li, Yi-Na] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Key Lab Tumor Microenvironm Respons Dr, Hengyang 421001, Peoples R China.
通讯机构:
[Guo, Y; Zeng, YF] U
Univ South China, Inst Pharm & Pharmacol, Hunan Prov Key Lab Tumor Microenvironm Respons Dr, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
Alkyl amines;Alkyl radicals;C(sp3)−N bond cleavage;Deaminative functionalization;Katritzky salts
期刊:
European Journal of Organic Chemistry
ISSN:
1434-193X
年:
2021
卷:
2021
期:
8
页码:
1215-1228
基金类别:
Financial support from the Foundation of Hu'nan Educational Committee (18C0476), Natural Science Foundation of Hunan Province (2020JJ5475) and Students Research Learning and Innovative Experimental Project of University of South China (S201910555145) is acknowledged.
机构署名:
本校为第一且通讯机构
院系归属:
药学与生物科学学院
摘要:
The amino group is one of the most prevalent functional groups present in a wide range of organic molecules, which has been widely applied in various organic synthesis and pharmaceuticals. Alkyl amines could be converted in a single step into Katritzky salts which could serve as alkyl radical precursors to construct C−C bonds and C−X bonds via C(sp3)−N cleavage. This deaminative functionalization could be carried out under transition-metal catalysis, photocatalysis, carbene catalysis or promoted by base. In this paper, recent developments in...

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