期刊论文

Research strategy and progress in Chlamydia vaccines

中文

中国人兽共患病学报

1002-2694

2021

37

05

455-461

10.3969/j.issn.1002-2694.2021.00.059

No.31570179:国家自然科学基金 No.2020JJ4084:湖南省自然科学基金 NO.2014-5:特殊病原体防控湖南省重点实验室项目 No.2015-351:湖南省分子靶标新药研究协同创新中心资助项目 No.2011-76:湖南省重点学科建设项目

本校为第一机构

衣原体（Chlamydia）是一种专性胞内寄生菌,衣原体的反复感染及其诱发的严重后遗症是人类健康的巨大威胁,因此,迫切需要开发安全有效的疫苗来预防和控制衣原体感染。尽管人类在衣原体免疫保护机制的研究和疫苗开发方面已经取得了一定的突破,但是结合疫苗安全性和免疫效果的全面考量,有效衣原体疫苗的成功出世仍然面临很多问题。本文就疫苗免疫效果的影响因素、合理设计有效衣原体疫苗的要素以及减毒活疫苗、灭活疫苗、亚单位疫苗、核酸疫苗、树突状细胞（dendritic cells, DC）疫苗和菌影（bacterial ghost, BG）疫苗等衣原体疫苗的研究现状进行简要论述。

Chlamydiais an obligatory intracellular parasite.Repeated Chlamydia infection and its severe sequelae pose a great threat to human health.Therefore,a safe and effective vaccine is urgently needed to prevent and control Chlamydiainfection.Although humans have made some breakthroughs in research on the immune protection mechanism against Chlamydia and the development of vaccines,the success of potential effective Chlamydia vaccines still faces many challenges in terms of vaccine safety and effectiveness.In this paper,the factors influencing vaccine immune effects;the elements of rational design ...