期刊论文

Research progress on the P1 protein of Mycoplasma pneumoniae

中文

中国人兽共患病学报

1002-2694

2021

37

04

362-367

10.3969/j.issn.1002-2694.2021.00.046

国家自然科学基金（No.81871256）~~；

本校为第一机构

支原体是一类可在无生命培养基中生长繁殖的最小的原核细胞型微生物,肺炎支原体作为常见的人类病原体,主要通过黏附呼吸道上皮细胞表面并释放多种有害物质破坏黏膜上皮从而引起肺炎等多种呼吸道感染性疾病。肺炎支原体的致病性与其黏附能力密切相关,实现细胞黏附的蛋白位于一个尖端结构——黏附细胞器上,其中包含1 627个氨基酸的P1蛋白作为主要黏附蛋白引起人们的关注。其强抗原性也为支原体肺炎的诊断和防治提供了方向。因此,对肺炎支原体P1蛋白的研究,有助于了解其致病机制,并做出针对性诊断、治疗和预防措施。

Mycoplasma pneumoniae,the smallest prokaryotic microorganism that can survive in inanimate medium,is a common human pathogen that mainly causes pneumonia and other respiratory infectious diseases by adhering to the surfaces of respiratory epithelial cells and releasing harmful substances that destroy the mucosal epithelium.The pathogenicity of M.pneumoniae is closely associated with its adhesion ability.The protein that mediates adhesion is located on a tip structure-attachment organelle,in which P1 protein,containing 1627 amino acids,has attracted attention as the main adhesion protein.Its st...