Heterogeneous nuclear ribonucleoprotein K is overexpressed and associated with poor prognosis in gastric cancer

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成果类型：

期刊论文

作者：

Yang, Ruirui;Zeng, Ying;Xu, Haifan;Chen, Zhuo;Xiang, Mengqin;...

通讯作者：

Zeng, Xi

作者机构：

[Xiang, Mengqin; Fu, Yun; Zeng, Min; Yang, Ruirui; Wang, Peihua; You, Qin; Zeng, Xi] Univ South China, Canc Res Inst, Key Lab Tumor Cellular & Mol Pathol, Coll Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

[Zeng, Ying] Univ South China, Sch Nursing, Hengyang 421001, Hunan, Peoples R China.

[Xu, Haifan; Chen, Zhuo] Univ South China, Affiliated Hosp 1, Dept Surg Oncol, Hengyang 421001, Hunan, Peoples R China.

[Yin, Yufang] Southern Illinois Univ, Sch Med, Dept Pharmacol, Springfield, IL 62702 USA.

[Zhong, Jing] Univ South China, Affiliated Hosp 1, Inst Clin Med, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Zeng, Xi] U

Univ South China, Canc Res Inst, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

hnRNP K;gastric cancer;tissue array;biomarker;prognosis

期刊：

ONCOLOGY REPORTS

ISSN：

1021-335X

年：

2016

卷：

期：

页码：

929-935

DOI：

10.3892/or.2016.4845

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81101643]; Foundation of the Construct Program of the Key Discipline in Hunan Province of China [2011-76]; Hunan Provincial Education Department document [2014-405]; Foundation of the Department of Science and Technology of Hunan Province [2012SK3152]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

护理学院

摘要：

Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is one of the major pre-mRNA-binding proteins, that is involved in translational modifications. In our previous studies, we found that hnRNP K is associated with human gastric cancer. The protein levels of hnRNP K were detected in cell lines and tissue microarrays. The correlation between hnRNP K expression and patient survival rate was evaluated by Kaplan-Meier survival analysis. In addition, we also detected hnRNP K expression in preoperative and postoperative serum samples from patients with gastric cancer, and serum samples from healthy v...

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Heterogeneous nuclear ribonucleoprotein K is overexpressed and associated with poor prognosis in gastric cancer

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