期刊论文

Zhang, ZW

英文

CURRENT CANCER DRUG TARGETS

1568-0096

2024

24

2

127-141

10.2174/1568009623666230512153741

National key research and development [2021YFE0192100]; Natural Science Foundation of Hunan Province [2019JJ40258, 2020JJ4083, 2021JJ30694]; Science and Technology Innovation Project of Hunan Province [2020SK51703]; Innovation and Entrepreneurship Training Program for College Students in Hunan Province [S202110555296]; Key Projects of Hunan Provincial Education Department [21A0285]; Natural Science Foundation of Hunan Provincial and Municipal Co-funding [2022JJ50029]; Key projects of Shaoyang Science and Technology Bureau [2021GZ031]

本校为第一且通讯机构

EBV promotes many cancers such as lymphoma, nasopharyngeal carcinoma, and gastric; Latent Membrane Protein 1 (LMP1) is considered to be a major oncogenic protein encoded by Epstein-Barr virus (EBV). LMP1 functions as a carcinogen in lymphoma and nasopharyngeal carcinoma, and LMP1 may also promote gastric cancer. The expression level of LMP1 in host cells is a key determinant in tumorigenesis and maintenance of virus specificity. By promoting cell immortalization and cell transformation, promoting cell proliferation, affecting immunity, and regu...