MicroRNA-377 inhibits atherosclerosis by regulating triglyceride metabolism through the DNA methyltransferase 1 in apolipoprotein e-knockout mice

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Chen, Ling-Yan;Xia, Xiao-Dan;Zhao, Zhen-Wang;Gong, Duo;Ma, Xiao-Feng;...

通讯作者：

Yin, Wei-Dong;Tang, Chao-Ke

作者机构：

[Gong, Duo; Wang, Si-Qi; Zhang, Qiang; Xia, Xiao-Dan; Tang, Chao-Ke; Zhao, Zhen-Wang; Yu, Xiao-Hua; Yin, Wei-Dong; Chen, Ling-Yan] Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Med Res Ctr,Hunan Prov Cooperat Innovat Ctr Mol T, Hengyang, Hunan, Peoples R China.

[Ma, Xiao-Feng] Univ South China, Dept Internal Med Cardiovasc, Nanhua Hosp, Hengyang, Hunan, Peoples R China.

[Dai, Xiao-Yan] Guangzhou Med Univ, Sch Pharmaceut Sci, Key Lab Mol Target & Clin Pharmacol, Guangzhou, Guangdong, Peoples R China.

[Dai, Xiao-Yan] Guangzhou Med Univ, Affiliated Hosp 5, Guangzhou, Guangdong, Peoples R China.

[Zheng, Xi-Long] Univ Calgary, Hlth Sci Ctr, Cumming Sch Med, Libin Cardiovasc Inst Alberta,Dept Biochem & Mol, Calgary, AB, Canada.

通讯机构：

[Yin, WD; Tang, CK] U

Univ South China, Inst Cardiovasc Res, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Atherosclerosis;DNA methyltransferase 1 (DNMT1);Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1);Lipoprotein lipase (LPL);MicroRNA-377

期刊：

Circulation Journal

ISSN：

1346-9843

年：

2018

卷：

期：

页码：

2861-2871

DOI：

10.1253/circj.CJ-18-0410

基金类别：

We gratefully acknowledge the patients for their participation in this study. This work was supported by grants from the National Natural Sciences Foundation of China (81570408), University of South China Innovation Foundation for Postgraduate (2017XCX03) and the construct program of the key discipline in Hunan Province, China (Basic Medicine Sciences in University of South China, Xiangjiaofa, No. [2011]76).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Background: Lipoprotein lipase (LPL) plays an important role in triglyceride metabolism. It is translocated across endothelial cells to reach the luminal surface of capillaries by glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1 (GPIHBP1), where it hydrolyzes triglycerides in lipoproteins. MicroRNA 377 (miR-377) is highly associated with lipid levels. However, how miR-377 regulates triglyceride metabolism and whether it is involved in the development of atherosclerosis remain largely unexplored. Methods and Resul...

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MicroRNA-377 inhibits atherosclerosis by regulating triglyceride metabolism through the DNA methyltransferase 1 in apolipoprotein e-knockout mice

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