Loss of MD1 Promotes Inflammatory and Apoptotic Atrial Remodelling in Diabetic Cardiomyopathy by Activating the TLR4/NF-& kappa;B Signalling Pathway

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Shi, Tonghuan;Wang, Guangji;Peng, Jianye;Chen, Manhua

通讯作者：

Chen, MH;Peng, JY

作者机构：

[Shi, Tonghuan] Wuhan Univ, Dept Cardiol, Renmin Hosp, Wuhan, Peoples R China.

[Shi, Tonghuan] Wuhan Univ, Hubei Key Lab Cardiol, Cardiovasc Res Inst, Wuhan, Peoples R China.

[Wang, Guangji; Chen, MH; Chen, Manhua] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Cardiol, Wuhan, Peoples R China.

[Wang, Guangji; Chen, MH; Chen, Manhua] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Key Lab Mol Diag Hubei Prov, Wuhan, Peoples R China.

[Peng, Jianye; Peng, JY] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Cardiovasc Med, Hengyang, Peoples R China.

通讯机构：

[Chen, MH ] H

[Peng, JY ] U

Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Cardiol, Wuhan, Peoples R China.

Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Key Lab Mol Diag Hubei Prov, Wuhan, Peoples R China.

Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Cardiovasc Med, Hengyang, Peoples R China.

语种：

英文

关键词：

Diabetic cardiomyopathy;Myeloid differentiation protein 1;Toll-like receptor 4;Atrial remodelling

期刊：

Research Reviews in Pharmacology

ISSN：

0031-7012

年：

2023

卷：

108

期：

页码：

311-319

DOI：

10.1159/000530081

基金类别：

Special Funds for Science and Technology Plan Project of Hengyang [2019jh426001]

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

Introduction: Myeloid differentiation protein 1 (MD1), a negative regulator of toll-like receptor 4 (TLR4), is widely expressed in the heart. Recent studies have shown that MD1 plays an important role in cardiac remodelling. However, the effects and potential mechanisms underlying MD1-mediated atrial remodelling in diabetic cardiomyopathy (DCM) remain unclear. Therefore, this study was designed to explore the role of MD1 in DCM-related atrial remodelling. Methods: MD1 knockout (MD1-KO) mice and wild-type (WT) littermates were injected with streptozotocin (STZ) to establish a diabetic mouse mod...

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Loss of MD1 Promotes Inflammatory and Apoptotic Atrial Remodelling in Diabetic Cardiomyopathy by Activating the TLR4/NF-& kappa;B Signalling Pathway

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