Diallyl disulfide inhibits colon cancer metastasis by suppressing Rac1-mediated epithelial-mesenchymal transition

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成果类型：

期刊论文

作者：

Xia, Longzheng;Lin, Jingguan;Su, Jian;Oyang, Linda;Wang, Heran;...

通讯作者：

Yujuan Zhou

作者机构：

[Chen, Xiaoyan; Xia, Longzheng; Zhou, Yujuan; Oyang, Linda; Wang, Heran; Liu, Wenbin; Luo, Xia; Liao, Qianjin; Tian, Yutong; Lin, Jingguan; Tang, Yanyan; Tan, Shiming; Liang, Jiaxin; Zhou, YJ] Cent S Univ, Xiangya Sch Med, Affiliated Canc Hosp, Key Lab Translat Radiat Oncol, 283 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.

[Chen, Xiaoyan; Xia, Longzheng; Zhou, Yujuan; Oyang, Linda; Wang, Heran; Liu, Wenbin; Luo, Xia; Liao, Qianjin; Tian, Yutong; Lin, Jingguan; Tang, Yanyan; Tan, Shiming; Liang, Jiaxin; Zhou, YJ] Hunan Canc Hosp, 283 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.

[Su, Qi; Su, Jian] Univ South China, Canc Res Inst, Hengyang, Hunan, Peoples R China.

通讯机构：

[Liao, QJ; Zhou, YJ] C

[Liao, QJ; Zhou, YJ] H

Cent S Univ, Xiangya Sch Med, Affiliated Canc Hosp, Key Lab Translat Radiat Oncol, 283 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.

Hunan Canc Hosp, 283 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.

语种：

英文

关键词：

colon cancer;diallyl disulfide;Ras related C3 botulinum toxin substrate1;epithelial-mesenchymal transition;metastasis

期刊：

ONCOTARGETS AND THERAPY

ISSN：

1178-6930

年：

2019

卷：

页码：

5713-5728

DOI：

10.2147/OTT.S208738

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81872281, 81402006, 81472595]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2019JJ40175, 2019JJ40183, 2018JJ1013]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Background: Prevention of epithelial-mesenchymal transition (EMT) provides a novel treatment strategy for tumor metastasis. Our previous studies have shown that diallyl disulfide (DADS) inhibits Ras related C3 botulinum toxin substrate1 (Rac1) expression, being a potential agent that suppresses migration and invasion of colon cancer cells. The study provides information on the underlying mechanisms. Methods: The expression of Rac1 and EMT markers (vimentin, N-cadherin and E-cadherin) in colon cancer samples was detected. Colon cancer cell lines treated with or without DADS were used to examine...

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Diallyl disulfide inhibits colon cancer metastasis by suppressing Rac1-mediated epithelial-mesenchymal transition

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