Diallyl disulfide inhibits TGF-β1-induced upregulation of Rac1 and β-catenin in epithelial-mesenchymal transition and tumor growth of gastric cancer

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成果类型：

期刊论文

作者：

Su, Bo;Su, Jian;Zeng, Ying;Ding, En;Liu, Fang;...

通讯作者：

Ai, XH;Su, Q

作者机构：

[Su, Bo; Ding, En; Tan, Tuo; Su, Qi; Ling, Hui; Su, Jian; Zeng, Ying; Xia, Hong; Zeng, Xi; Liu, Fang] Hunan Prov Univ, Key Lab Canc Cellular & Mol Pathol, Canc Res Inst, Changsha, Hunan, Peoples R China.

[Su, Bo; Su, Jian] Hunan Prov Univ, Key Lab Pharmacoprote, Inst Pharm & Pharmacol, Changsha, Hunan, Peoples R China.

[Su, Jian] Univ South China, Affiliated Hosp 2, Dept Pathol, Hengyang 421001, Hunan, Peoples R China.

[Su, Bo; Ding, En; Tan, Tuo; Su, Qi; Ai, Xiao-Hong; Ling, Hui; Jiang, Hao; Xia, Hong; Zeng, Ying; Wu, You-Hua; Zeng, Xi; Liu, Fang] Univ South China, Affiliated Hosp 1, Ctr Gastr Canc Res Hunan Prov, 69 Chuan Shan Rd, Hengyang 421001, Hunan, Peoples R China.

[Ding, En; Tan, Tuo] First Affiliated Hosp, Dept Oncol, Hunan Coll Tradit Chinese Med, Zhuzhou 412012, Hunan, Peoples R China.

通讯机构：

[Su, Q ; Ai, XH ] U

Univ South China, Affiliated Hosp 1, Ctr Gastr Canc Res Hunan Prov, 69 Chuan Shan Rd, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Hunan Prov Univ, Key Lab Canc Cellular & Mol Pathol, Canc Res Inst, 28 Western Changshen Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

beta catenin;CD34 antigen;diallyl disulfide;Ki 67 antigen;Rac1 protein;transforming growth factor beta1;uvomorulin;vimentin;allyl compound;antineoplastic agent;beta catenin;diallyl disulfide;disulfide;Rac1 protein;RAC1 protein, human;TGFB1 protein, human;transforming growth factor beta1;animal experiment;animal model;animal tissue;Article;cancer inhibition;cell invasion;controlled study;down regulation;drug effect;epithelial mesenchymal transition;gene expression regulation;human;human cell;mouse;nonhuman;nude mouse;priority journal;protein expression;protein function;stomach cancer;upregulation;animal;cell proliferation;drug screening;epithelial mesenchymal transition;metabolism;stomach tumor;tumor cell line;tumor invasion;Allyl Compounds;Animals;Antineoplastic Agents;beta Catenin;Cell Line, Tumor;Cell Proliferation;Disulfides;Epithelial-Mesenchymal Transition;Gene Expression Regulation, Neoplastic;Humans;Mice;Neoplasm Invasiveness;rac1 GTP-Binding Protein;Stomach Neoplasms;Transforming Growth Factor beta1;Up-Regulation;Xenograft Model Antitumor Assays

期刊：

ONCOLOGY REPORTS

ISSN：

1021-335X

年：

2018

卷：

期：

页码：

2797-2806

DOI：

10.3892/or.2018.6345

基金类别：

The present study was supported by The National Natural Scientific Foundation of China (nos. 31000629, 31100935, 81102854, 81374013 and 81641112), The Key Project of Scientific Research Foundation of Hunan Province Education Department of China (no. 09A077), The Patency Foundation of Innovation Platform of Hunan Provincial University of China (no. 09K074), The Key Project of Scientific Research Foundation of Health and Family Planning Committee of Hunan Province (no. A2015-2), The Scientific Research Foundation of Health and Family Planning Committee of HunanProvince(no.B2015-182)and The Construct Program of the Key Discipline in Hunan Province of China (no. 2011-76). The present study was supported by The National Natural Scientific Foundation of China (nos. 31000629, 31100935, 81102854, 81374013 and 81641112), The Key Project of Scientific Research Foundation of Hunan Province Education Department of China (no. 09A077), The Patency Foundation of Innovation Platform of Hunan Provincial University of China (no. 09K074), The Key Project of Scientific Research Foundation of Health and Family Planning Committee of Hunan Province (no. A2015‑2), The Scientific Research Foundation of Health and Family Planning Committee of Hunan Province (no. B2015‑182) and The Construct Program of the Key Discipline in Hunan Province of China (no. 2011‑76).

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

Transforming growth factor-beta 1 (TGF-beta 1) has been demonstrated to promote epithelial-mesenchymal transition (EMT), invasion and proliferation in tumors via the activation of Rac1 and beta-catenin signaling pathways. The present study investigated the effects of diallyl disulfide (DADS) on TGF-beta 1-induced EMT, invasion and growth of gastric cancer cells. TGF-beta 1 treatment augmented EMT and invasion, concomitantly with increased expression of TGF-beta 1, Rac1 and beta-catenin in gastric cancer cells. DADS downregulated the expression levels of TGF-beta 1, Rac1 and beta-catenin. DADS,...

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Diallyl disulfide inhibits TGF-β1-induced upregulation of Rac1 and β-catenin in epithelial-mesenchymal transition and tumor growth of gastric cancer

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