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Redox-responsive MXene-SS-PEG nanomaterials for delivery of doxorubicin

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成果类型:
期刊论文
作者:
Wen, Huixiang;Liu, Pengfei;Jiang, Zichao;Peng, Haining;Liu, Huijun
通讯作者:
Huijun Liu
作者机构:
[Jiang, Zichao; Peng, Haining; Liu, Huijun; Wen, Huixiang; Liu, Pengfei] Univ South China, Dept Chem & Chem Engn, Hengyang 421001, Hunan, Peoples R China.
[Liu, Huijun; Wen, Huixiang] Univ South China, Hunan Key Lab Design & Applicat Actinide Complexes, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Huijun Liu] D
Department of Chemistry and Chemical Engineering, University of South China, Hengyang, Hunan 421001, China<&wdkj&>Hunan Key Laboratory for the Design and Application of Actinide Complexes, University of South China, Hengyang, Hunan 421001, China
语种:
英文
关键词:
MXene;GSH;Redox-responsive;PEG;Drug delivery system
期刊:
Inorganic Chemistry Communications
ISSN:
1387-7003
年:
2023
卷:
147
页码:
110227
基金类别:
This work was supported by the National Natural Science Foundation of China (No. 11375084 ), Natural Science Foundation of Hunan Province (No. 2021JJ50092 ).
机构署名:
本校为第一机构
院系归属:
化学化工学院
摘要:
MXene has a large surface area, which gives medicinal drug molecules enough anchor sites. This property can be utilized to design incredibly effective intracellular drug delivery systems. In this work, a non-toxic and safe Ti3C2Tx materials was chosen in MXene. Ti3C2Tx MXene was decorated with Methoxy Polyethylene Glycol (PEG) by a linker cystamine dihydrochloride disulfide bonds (-SS-). The DOX delivery system of Ti3C2Tx MXene modified by PEG was constructed. To further examine the system's potential as a cancer treatment, in vitro tests were conducted. The outcomes demonstrated the potential...

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