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Emerging Roles of FTO in Neuropsychiatric Disorders

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成果类型:
期刊论文
作者:
Chang, Rui;Huang, Zeyi;Zhao, Size;Zou, Ju;Li, Yukun;...
通讯作者:
Tan, S.;Zou, J.;Li, Y.
作者机构:
[Li, Yukun; Tan, Sijie; Zhao, Size; Chang, Rui; Huang, Zeyi; Zou, Ju] Univ South China, Inst Clin Anat & Reprod Med, Sch Basic Med, Hengyang Med Sch, Hunan 421001, Hunan, Peoples R China.
通讯机构:
[Size Zhao; Rui Chang; Sijie Tan; Ju Zou; Zeyi Huang; Yukun Li] D
Department of Histology and Embryology, Institute of Clinical Anatomy and Reproductive Medicine, School of Basic Medicine, Hengyang Medical School, University of South China, Hunan, China
语种:
英文
关键词:
Introduction;Materials and Methods;Results;Discussion;Conclusion;Abstract;Data Availability;Additional Points;Ethical Approval;Consent;Disclosure;Conflicts of Interests;Authors’ Contributions;Funding Statement;Acknowledgements;Acknowledgments;Supplementary Materials;Reference;Dataset Description;Dataset Files;Abstract;Introduction;Introduction and Materials;Introduction and Methods;Materials;Materials and Methods;Methods;Results;Discussion;Results and Discussion;Discussion and Conclusion;Results and Conclusion;Conclusion;Conclusions;Data Availability;Additional Points;Ethical Approval;Consent;Disclosure;Conflicts of Interest;Authors’ Contributions;Funding Statement;Acknowledgements;Supplementary Materials;References;Appendix;Abbreviations;Preliminaries;Introduction and Preliminaries;Notation;Proof of Theorem;Proofs;Analysis of Results;Examples;Numerical Example;Applications;Numerical Simulation;Model;Model Formulation;Systematic Palaeontology;Nomenclatural Acts;Taxonomic Implications;Experimental;Synthesis;Overview;Characterization;Background;Experimental;Theories;Calculations;Model Verification;Model Implementation;Geographic location;Study Area;Geological setting;Data Collection;Field Testing;Data and Sampling;Dataset;Literature Review;Related Works;Related Work;System Model;Methods and Data;Experimental Results;Results and Analysis;Evaluation;Implementation;Case Presentation;Case Report;Search Terms;Case Description;Case Series;Background;Limitations;Additional Points;Case;Case 1;Case 2 etc.;Concern Details;Retraction Details;Copyright;Related Articles
期刊:
BioMed Research International
ISSN:
2314-6133
年:
2022
卷:
2022
基金类别:
National Science Foundation of China [NSFC 81301144]; Hunan Provincial Natural Science Foundation [2019JJ40250]; Research Project of Hunan Education Department [21C0312]; College Students Science and Technology Innovation Project of the University of South China and Hunan Province [210XCX486, 210XCX510, 200XCX322]
机构署名:
本校为第一机构
院系归属:
医学院
摘要:
FTO (fat mass and obesity associated) is a recently discovered gene related to obesity and expressed in various tissues of the human body, especially with high expression in the brain. Earlier studies have found that FTO is involved in several biological processes, including brain development and function. In particular, recent studies have found that FTO is a demethylase of N6-methyladenosine (m6A) and it can affect neurological function through the m6A modification of mRNA. At present, a number of studies have shown that FTO is associated wit...

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