Protective Immunity against Chlamydia psittaci Lung Infection Induced by a DNA Plasmid Vaccine Carrying CPSIT_p7 Gene Inhibits Dissemination in BALB/c Mice

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成果类型：

期刊论文

作者：

Wang, Chuan;Jin, Yingqi;Wang, Jiewen;Zheng, Kang;Lei, Aihua;...

通讯作者：

Yimou Wu<&wdkj&>Shuzhi Wang

作者机构：

[Lu, Chunxue; Wu, Yimou; Lei, Aihua; Wang, Jiewen; Zheng, Kang; Jin, Yingqi; Wang, Chuan; Wang, Shuzhi] Univ South China, Inst Pathogen Biol, Hengyang Med Coll, Sch Basic Med, Hengyang 421001, Peoples R China.

[Lu, Chunxue; Wu, Yimou; Lei, Aihua; Wang, Jiewen; Zheng, Kang; Jin, Yingqi; Wang, Chuan; Wang, Shuzhi] Univ South China, Hunan Prov Key Lab Special Pathogens Prevent & Con, Hengyang 421001, Peoples R China.

[Zheng, Kang] Hengyang Cent Hosp, Dept Clin Lab, Hengyang 421001, Peoples R China.

[Wang, Shuzhi] Univ South China, Hengyang Med Coll, Sch Pharmaceut Sci, Dept Pharmacol, Hengyang 421001, Peoples R China.

通讯机构：

[Yimou Wu; Shuzhi Wang] A

Authors to whom correspondence should be addressed.<&wdkj&>Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, University of South China, Hengyang 421001, China<&wdkj&>Institute of Pathogenic Biology, School of Basic Medicine, Hengyang Medical College, University of South China, Hengyang 421001, China<&wdkj&>Authors to whom correspondence should be addressed.<&wdkj&>Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, University of South China, Hengyang 421001, China<&wdkj&>Institute of Pathogenic Biology, School of Basic Medicine, Hengyang Medical College, University of South China, Hengyang 421001, China<&wdkj&>Department of Pharmacology, School of Pharmaceutical Science, Hengyang Medical College, University of South China, Hengyang 421001, China

语种：

英文

关键词：

Chlamydia psittaci;CPSIT_p7;DNA vaccine;dissemination;protective immunity

期刊：

International Journal of Molecular Sciences

ISSN：

1422-0067

年：

2023

卷：

期：

页码：

7013-

DOI：

10.3390/ijms24087013

基金类别：

Methodology, C.W., K.Z. and C.L.; Software, A.L. and C.L.; Validation, A.L.; Formal analysis, C.W.; Investigation, C.W., Y.J. and J.W.; Writing—original draft, C.W. and S.W.; Writing—review & editing, Y.W.; Supervision, S.W.; Project administration, S.W. and Y.W.; Funding acquisition, Y.W. All authors have read and agreed to the published version of the manuscript. This work was supported by the Natural Science Foundation of Hunan Province under Grant No. 2021JJ40455, Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation under Grant No. 2014-5, the Projects of Hunan Education Authorities under Grant No. 22B0417, and the Hengyang Science and Technology Planning Project under Grant No. 202250045337.

机构署名：

本校为第一机构

院系归属：

医学院

药学与生物科学学院

摘要：

Chlamydia psittaci (C. psittaci), a zoonotic pathogen, poses a potential threat to public health security and the development of animal husbandry. Vaccine-based preventative measures for infectious diseases have a promising landscape. DNA vaccines, with many advantages, have become one of the dominant candidate strategies in preventing and controlling the chlamydial infection. Our previous study showed that CPSIT_p7 protein is an effective candidate for a vaccine against C. psittaci. Thus, this study evaluated the protective immunity of pcDNA3.1(+)/CPSIT_p7 against C. psittaci infection in BAL...

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Protective Immunity against Chlamydia psittaci Lung Infection Induced by a DNA Plasmid Vaccine Carrying CPSIT_p7 Gene Inhibits Dissemination in BALB/c Mice

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