期刊论文

Xiao, Jianhua

英文

International Journal of Clinical and Experimental Medicine

1940-5901

2018

11

2

1105-1114

Foundation of Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation [2014-5]; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [2015-351]

本校为第一且通讯机构

Objective: Zymosan A is a type of fungus polysaccharide that is derived from the cell wall of yeast and induces immune responses associated with fungal infection. In this study, our aim was to observe the expression and degradation of the following cytokines: TNF-alpha, CXCL1, IL-10 and IL-23a. These cytokines were induced by Zymosan A via primary peritoneal macrophages (pM Phi s), and they had more AU-rich elements (ARE) within their 3'-UTR mRNA sequence. Additionally, we would like to explore the mechanism underlying the p38 regulation of the ARE-mRNA stability of the related cytokines in th...