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Repair of avascular meniscal injuries using juvenile meniscal fragments: An in vitro organ culture study

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成果类型:
期刊论文
作者:
Dai, Zhu;Li, Kanghua*;Chen, Zhiwei;Liao, Ying;Yang, Lezhong;...
通讯作者:
Li, Kanghua
作者机构:
[Li, Kanghua; Dai, Zhu] Cent S Univ, Xiangya Hosp, Dept Orthoped, Changsha 410078, Hunan, Peoples R China.
[Chen, Zhiwei; Dai, Zhu; Liu, Chunlei; Yang, Lezhong; Liao, Ying] South China Univ, Affiliated Hosp 1, Dept Orthoped, Hengyang 421001, Hunan, Peoples R China.
[Ding, Wenjun] South China Univ, Affiliated Hosp 1, Clin Res Inst, Hengyang 421001, Hunan, Peoples R China.
[Li, Kanghua] Cent S Univ, Xiangya Hosp, Dept Orthoped, 87 Xiangya Rd, Changsha 410078, Hunan, Peoples R China.
通讯机构:
[Li, Kanghua] C
Cent S Univ, Xiangya Hosp, Dept Orthoped, 87 Xiangya Rd, Changsha 410078, Hunan, Peoples R China.
语种:
英文
关键词:
collagen type 1;collagen type 2;animal experiment;animal model;article;avascular meniscal injury;biomechanics;bone graft;confocal laser microscopy;confocal microscopy;controlled study;explant;healing;histopathology;immunohistochemistry;in vitro study;juvenile meniscal allograft;knee meniscus rupture;materials testing;meniscal repair;minced meniscal fragment;nonhuman;organ culture;priority journal;tissue repair;in vitro;injury;integrative repair;meniscus;organ culture;Age Factors;Animals;Biomechanics;Collagen Type I;Collagen Type II;Immunohistochemistry;Knee Injuries;Menisci, Tibial;Organ Culture Techniques;Reconstructive Surgical Procedures;Shear Strength;Swine;Transplantation, Homologous;Wound Healing
期刊:
Journal of Orthopaedic Research
ISSN:
0736-0266
年:
2013
卷:
31
期:
10
页码:
1514-1519
基金类别:
Provincial Science and Technology Department of Hunan#&#&#2012SK3156 Provincial Science Foundation of Hunan#&#&#10JJ3094
机构署名:
本校为其他机构
院系归属:
医学院
摘要:
We investigated whether the implantation of juvenile allograft and minced meniscal fragments could improve the healing of avascular meniscal injuries, which cannot heal spontaneously. Concentric cylindrical explants were excised from the inner two-thirds of swine medial menisci. The inner cylinder consisted of a "sandwich" structure, with minced juvenile meniscal fragments, juvenile meniscal columns, minced mature meniscal fragments, or mature meniscal columns implanted in the middle. The explants were cultured in vitro for 2, 4, or 6 weeks. Interfacial meniscal repair was assessed by histolog...

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