期刊论文

中文

中国脊柱脊髓杂志

1004-406X

2000

10

5

274-276

10.3969/j.issn.1004-406X.2000.05.005

本校为其他机构

目的 :探讨镁对脊髓损伤后继发性水肿的影响。方法 :按改良的Allen′s重物打击法制备兔脊髓损伤模型 ,将动物分为 5组 ,A组为正常对照组 ;B、D组分别为损伤后 2 4h及 48h不用镁组 ;C、E组分别为损伤后 2 4h及 48h用镁组 ,于脊髓损伤后 30min一次性给予硫酸镁 （6 0 0mg/kg ,皮下注射 ）。分别取材测定伤段脊髓组织水、钙、镁含量及观察局部的组织病理学改变。结果 :各损伤组脊髓组织含水量显著高于正常对照组 （P

Objective:To study the effect of postinjury treatment with Mg 2+ on spinal cord edema after traumatic spinal cord injury.Method:Forty rabbits were randomly assigned to five experimental groups on the basis of the administration of magnesium and the harvest time of spinal cord tissue specimens:Sham(Group A);Spinal cord injury(SCI) 24 hours(Group B);SCI with administration of Mg 2+ half an hour postinjury 24 hours(Group C);SCI 48 hours(Group D);SCI with administration of Mg 2+ half an hour postinjury 48 hours(Group E).The SCI animal models were m...