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Integrated Pharmaco-Bioinformatics Approaches and Experimental Verification To Explore the Effect of Britanin on Nonalcoholic Fatty Liver Disease

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成果类型:
期刊论文
作者:
Dou, Chengyun;Zhu, Hongbo;Xie, Xia;Huang, Cuiqin;Cao, Chuangjie
通讯作者:
Cao, CJ
作者机构:
[Dou, Chengyun; Xie, Xia] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Infect Dis, Hengyang 421001, Hunan, Peoples R China.
[Zhu, Hongbo] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Med Oncol, Hengyang 421001, Hunan, Peoples R China.
[Cao, Chuangjie; Cao, CJ; Huang, Cuiqin] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pathol, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Cao, CJ ] U
Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pathol, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
期刊:
ACS OMEGA
ISSN:
2470-1343
年:
2024
卷:
9
期:
7
页码:
8274-8286
基金类别:
Health Commission of Hunan Province [202103082238, 202104082246]; Scientific Research Project of Health Commission of Hunan Province of China
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Nonalcoholic fatty liver disease (NAFLD) is a prevalent global liver disorder, posing substantial health risks. Britanin, a bioactive sesquiterpene lactone extracted from Inula japonica, has demonstrated antidiabetic, hypolipidemic, and hepatoprotective attributes. Nonetheless, the precise impact of Britanin on NAFLD and the intricate biological mechanisms underpinning this interaction remain unexplored. We integrated computer-aided methods to unearth shared biological targets and signaling pathways associated with both Britanin and NAFLD. A network was constructed by compiling putative target...

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