Two-dimensional design strategy to construct smart dual-responsive fluorescent probe for the precise tracking of ischemic stroke

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成果类型：

期刊论文

作者：

Zeng, Jiayu;Liu, Minhui;Yang, Ting;Huang, Jia;Li, Songjiao;...

通讯作者：

He, Longwei;Zhou, J;He, LW

作者机构：

[Liu, Minhui; Zeng, Jiayu; Zhou, Jia; Zhang, Wanting; He, Longwei; Yang, Ting; Li, Songjiao; He, LW; Huang, Jia; Zhou, J] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Ultrasound Med, Hengyang 421002, Peoples R China.

[Liu, Minhui; He, LW; Zeng, Jiayu; He, Longwei; Yang, Ting; Li, Songjiao; Cheng, Dan] Univ South China, Sch Pharmaceut Sci, Hengyang Med Sch, MOE Key Lab Rare Pediat Dis, Hengyang 421002, Peoples R China.

[He, LW; Zeng, Jiayu; He, Longwei; Cheng, Dan] Univ South China, Sch Basic Med Sci, Hengyang Med Sch, Hengyang 421001, Peoples R China.

[Cheng, Dan] Univ South China, Affiliated Nanhua Hosp, Clin Res Inst, Hengyang Med Sch,Dept Gastroenterol, Hengyang 421002, Peoples R China.

通讯机构：

[He, LW ; He, LW; Zhou, J ] U

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Ultrasound Med, Hengyang 421002, Peoples R China.

Univ South China, Sch Pharmaceut Sci, Hengyang Med Sch, MOE Key Lab Rare Pediat Dis, Hengyang 421002, Peoples R China.

Univ South China, Sch Basic Med Sci, Hengyang Med Sch, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Ischemic stroke;Ferroptosis;Viscosity;Cysteine;Mitochondria;Fluorescent probe

期刊：

中国化学快报：英文版

ISSN：

1001-8417

年：

2025

卷：

期：

页码：

110166

DOI：

10.1016/j.cclet.2024.110166

基金类别：

Natural Science Foundation of Hunan Province [2022JJ30484, 2022JJ10042, 2023JJ50157]; Start-up funds of University of South China [201RGC012, 20XQD030]; Research Foundation of Education Bureau of Hunan Province [22B0418]; Education Ministry's Collaborative Education Program with Industry of China [220902102225257, 230902999244208]; Ministry of Education of China: "Chunhui Plan" [HZKY20220359]; Open Fund of State Key Laboratory of Chemo/Biosensing and Chemometrics [2021013, 2021015]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Early recognition is key to improving the prognosis of ischemic stroke (IS), while available imaging methods tend to target events that have already undergone ischemia. A new method to detect early IS is urgently needed, as well as further study of its mechanisms. Viscosity and cysteine (Cys) levels of mitochondria have been associated with ferroptosis and IS. It is possible to identify IS and ferroptosis accurately and early by monitoring changes in mitochondrial Cys and viscosity simultaneously. In this work, a viscosity/Cys dual-responsive m...

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Two-dimensional design strategy to construct smart dual-responsive fluorescent probe for the precise tracking of ischemic stroke

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