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Two-dimensional design strategy to construct smart dual-responsive fluorescent probe for the precise tracking of ischemic stroke

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成果类型:
期刊论文
作者:
Jiayu Zeng;Minhui Liu;Ting Yang;Jia Huang;Songjiao Li;...
通讯作者:
Longwei He<&wdkj&>Jia Zhou
作者机构:
[Jia Huang; Wanting Zhang; Jia Zhou] Department of Ultrasound Medicine, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421002, China
MOE Key Lab of Rare Pediatric Diseases, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang 421002, China
School of Basic Medical Science, Hengyang Medical School, University of South China, Hengyang 421001, China
Department of Gastroenterology, Clinical Research Institute, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, China
[Jiayu Zeng; Longwei He] Department of Ultrasound Medicine, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421002, China<&wdkj&>MOE Key Lab of Rare Pediatric Diseases, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang 421002, China<&wdkj&>School of Basic Medical Science, Hengyang Medical School, University of South China, Hengyang 421001, China
通讯机构:
[Longwei He; Jia Zhou] D
Department of Ultrasound Medicine, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421002, China<&wdkj&>MOE Key Lab of Rare Pediatric Diseases, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang 421002, China<&wdkj&>School of Basic Medical Science, Hengyang Medical School, University of South China, Hengyang 421001, China<&wdkj&>Department of Ultrasound Medicine, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421002, China
语种:
英文
期刊:
中国化学快报:英文版
ISSN:
1001-8417
年:
2025
卷:
36
期:
5
页码:
110166
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Early recognition is key to improving the prognosis of ischemic stroke (IS), while available imaging methods tend to target events that have already undergone ischemia. A new method to detect early IS is urgently needed, as well as further study of its mechanisms. Viscosity and cysteine (Cys) levels of mitochondria have been associated with ferroptosis and IS. It is possible to identify IS and ferroptosis accurately and early by monitoring changes in mitochondrial Cys and viscosity simultaneously. In this work, a viscosity/Cys dual-responsive m...

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