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Indole-quinoline transmutation enabled by a formal rhodium carbynoid

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成果类型:
期刊论文
作者:
Cui Xin;Zi-Jian Zhao;Wei-Min He
通讯作者:
Zi-Jian Zhao<&wdkj&>Wei-Min He
作者机构:
[Cui Xin] Key Laboratory of Food & Environment & Drug Monitoring and Testing of Universities in Hunan Province, Hunan Police Academy, Changsha, 410138, China
[Zi-Jian Zhao] School of Chemistry and Materials Science, Huaihua University, Huaihua, 418000, China
School of Chemistry and Chemical Engineering, University of South China, Hengyang, 421001, China
College of Chemical Engineering, Nanjing Forestry University, Nanjing, 210037, China
[Wei-Min He] School of Chemistry and Chemical Engineering, University of South China, Hengyang, 421001, China<&wdkj&>College of Chemical Engineering, Nanjing Forestry University, Nanjing, 210037, China
通讯机构:
[Zi-Jian Zhao; Wei-Min He] S
School of Chemistry and Chemical Engineering, University of South China, Hengyang, 421001, China<&wdkj&>College of Chemical Engineering, Nanjing Forestry University, Nanjing, 210037, China<&wdkj&>School of Chemistry and Materials Science, Huaihua University, Huaihua, 418000, China
语种:
英文
期刊:
中国化学快报(英文)
ISSN:
1001-8417
年:
2025
页码:
111583
机构署名:
本校为通讯机构
院系归属:
化学化工学院
摘要:
The recent investigation on the ring-expansion of indoles to quinolines via a rhodium-catalyzed single-carbon insertion process has been highlighted. This creative strategy, developed by Han and co-workers, employs an α-diazotrifluoroethyl sulfonium salt they developed as a trifluoromethyl cationic carbyne (CF3C+:) precursor to deliver structurally diverse 3-trifluoromethylquinolines in good to high yields (up to 91%). In addition, the practicability of this methodology is demonstrated by the late-stage skeletal editing of pharmaceuticals and ...

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