On-resin peptide ligation via C-terminus benzyl ester

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成果类型：

期刊论文、会议论文

作者：

Zhou, Bin;Faridoon*;Tian, Xiaobo;Li, Jian;Guan, Dongliang;...

通讯作者：

Guo, Yu;Faridoon;Huang, Wei

作者机构：

[Zhou, Bin; Guo, Yu; Zheng, Xing] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

[Zhou, Bin; Faridoon; Huang, Wei; Guan, Dongliang; Tian, Xiaobo; Huang, W; Li, Jian] Chinese Acad Sci, Shanghai Inst Mat Med, CAS Ctr Excellence Mol Cell Sci, Ctr Biotherapeut Discovery Res,CAS Key Lab Recept, Shanghai 201203, Peoples R China.

[Faridoon; Huang, Wei; Guan, Dongliang; Li, Jian] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.

通讯机构：

[Guo, Yu] U

[Faridoon; Huang, W] C

Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

Chinese Acad Sci, Shanghai Inst Mat Med, CAS Ctr Excellence Mol Cell Sci, Ctr Biotherapeut Discovery Res,CAS Key Lab Recept, Shanghai 201203, Peoples R China.

语种：

英文

关键词：

On-resin peptide ligation;Peptide benzyl ester;Native chemical ligation;Auxiliary-assisted peptide ligation;Peptide elongation

期刊：

中国化学快报：英文版

ISSN：

1001-8417

年：

2018

卷：

期：

页码：

1123-1126

会议名称：

15th Chinese International Peptide Symposium (CPS)

会议时间：

JUL 04-06, 2018

会议地点：

Tsinghua Univ, Shenzhen, PEOPLES R CHINA

会议主办单位：

Tsinghua Univ

出版地：

360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA

出版者：

ELSEVIER SCIENCE INC

DOI：

10.1016/j.cclet.2018.03.021

基金类别：

This work was supported by Hunan Provincial Innovation Foundation for Postgraduate (China) (No. CX2017B546) and the National Natural Science Foundation of China (No. 21572244). We thank Dr. Houchao Tao and Dr. Fei Zhao in iHuman Institute, ShanghaiTech University and Dr. Jingjing Shi in SIMM for their kind help in MS determination.

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Here, we report a new approach of on-resin peptide ligation using C-terminal benzyl ester as the stabilized precursor of thioester, which enables both N-terminal elongation and C-terminal peptide ligation on a Rink Amide resin. On-resin native chemical ligation and auxiliary-assisted peptide ligation were successfully achieved. This method is compatible to both protected and unprotected peptide fragments and has potential a...

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On-resin peptide ligation via C-terminus benzyl ester

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