期刊论文

Leung, Polly H. M.

英文

中国化学快报：英文版

1001-8417

2018

29

2

313-316

10.1016/j.cclet.2017.09.052

This study was supported by the National Natural Science Foundation of China （Nos. 81401512, 41606186）, the Scientific Research Fund of Hunan Provincial Education Department （No. 14B157）, China Postdoctoral Science Foundation （No. 2016M602419）, and the Hong Kong Scholars Program （No. XJ2015022）.

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Bacterial quorum sensing(QS) molecules are involved in the coordination of certain behaviors such as biofilm formation, virulence and antibiotic resistance. QS molecules(autoinducers) and their corresponding receptors have been recognized as important therapeutic targets for drug-resistant infections and biofilm-associated infections(BAI). This study assessed the multiple biological effects of homogentisic acid y-lactone(HgAL), a furanone derivative. The anti-QS and anti-biofilm effects of HgAL against PAO1 strain were evaluated using CLSM, SEM, HPLC and other biochemical methods The results s...

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