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Dynamic consequences of mutating the typical HPGG motif of apocytochrome b_5 revealed by computer simulation

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成果类型:
期刊论文
作者:
Lin, Ying Wu*;Ying, Tian Lei;Liao, Li Fu
通讯作者:
Lin, Ying Wu
作者机构:
[Liao, Li Fu; Lin, Ying Wu] Univ S China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
[Lin, Ying Wu] Univ Illinois, Dept Chem, Urbana, IL 61801 USA.
[Ying, Tian Lei] Fudan Univ, Dept Chem, Biol Chem Lab, Shanghai 200433, Peoples R China.
通讯机构:
[Lin, Ying Wu] U
Univ S China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
Apocytochrome b5;Heme-binding motif;HPGG;Molecular dynamics simulation
关键词(中文):
计算机模拟;动态突变;分子动力学模拟;细胞色素B5;血红素;蛋白质
期刊:
中国化学快报:英文版
ISSN:
1001-8417
年:
2009
卷:
20
期:
5
页码:
631-634
基金类别:
This work was supported by the initial foundation for Ph.D. introduced into University of South China (No. 506XJQ06001). NAMD and VMD were developed by the Theoretical Biophysics Group in the Beckman Institute for Advanced Science and Technology at the University of Illinois at Urbana-Champaign, USA. We also wish to thank Prof. Shun Hirota at Nara Institute of Science and Technology, Japan, for critical review of this paper.
机构署名:
本校为第一且通讯机构
院系归属:
化学化工学院
摘要:
Apocytochrome b5 with a typical heme-binding motif of HPGG, and its variants with mutated motifs, GPGG, GPGH, HVGG, and HPGP, have been subjected to molecular dynamics simulation. Comparison of the dynamic consequences has revealed the crucial role of HPGG in assembling the heme group of cytochrome b5 and in modulating protein structure, pro...
摘要(中文):
Apocytochrome b_5 with a typical heme-binding motif of HPGG,and its variants with mutated motifs,GPGG,GPGH,HVGG, and HPGP,have been subjected to molecular dynamics simulation.Comparison of the dynamic consequences has revealed the crucial role of HPGG in assembling the heme group of cytochrome b_5 and in modulating prote...

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