The incidence of Type 2 diabetes mellitus (T2DM) has increased worldwide. This study investigated the effect of a herbal extract, named as Baihu decoction (BHD), in treating T2DM by using mouse adipose cells and a mouse T2DM model. Mouse 3T3-L1 preadipocytes were cultured in DMEM culture medium and used for experiments when about 90% fat-differentiated cells were mature. The KM male mouse diabetes model was established by injecting streptozotocin. Thirty two KM T2DM mice were randomly divided into 4 groups, with 8 mice in each group. Enzyme-linked immunosorbent assays (ELISA) and Reverse Trans...