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A herbal extract treats type 2 diabetes mellitus effectively by down-regulating expression of CD14

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成果类型:
期刊论文
作者:
Li, Lifang;Yan, Dewen;Zou, Yan;Zhang, Tingji;Lin, Guangfeng;...
通讯作者:
Xiao, Jianhua
作者机构:
[Li, Lifang; Xiao, Jianhua] Univ South China, Hengyang Med Coll, Inst Pathogen Biol, 28 Changsheng Rd, Hengyang 421001, Peoples R China.
[Li, Lifang; Zou, Yan; Yan, Dewen; Lin, Guangfeng; Zhang, Tingji] Second Peoples Hosp Shenzhen, Shenzhen 518037, Peoples R China.
通讯机构:
[Xiao, Jianhua] U
Univ South China, Hengyang Med Coll, Inst Pathogen Biol, 28 Changsheng Rd, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
Type 2 diabetes mellitus;Baihu decoction;adipose tissue;chronic inflammation;CD14
期刊:
International Journal of Clinical and Experimental Medicine
ISSN:
1940-5901
年:
2019
卷:
12
期:
2
页码:
1535-1544
基金类别:
Science and technology project of Shenzhen city [JCYJ20150330102720160]; Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation [2014-5]; Hunan Province Cooperative innovation Center for Molecular Target New Drug Study [2015-8]
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
The incidence of Type 2 diabetes mellitus (T2DM) has increased worldwide. This study investigated the effect of a herbal extract, named as Baihu decoction (BHD), in treating T2DM by using mouse adipose cells and a mouse T2DM model. Mouse 3T3-L1 preadipocytes were cultured in DMEM culture medium and used for experiments when about 90% fat-differentiated cells were mature. The KM male mouse diabetes model was established by injecting streptozotocin. Thirty two KM T2DM mice were randomly divided into 4 groups, with 8 mice in each group. Enzyme-linked immunosorbent assays (ELISA) and Reverse Trans...

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