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One-pot synthesis of monodisperse dual-functionalized polyethylene glycols through macrocyclic sulfates

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成果类型:
期刊论文
作者:
Lv, Xiaoyan;Zheng, Xing;Yang, Zhigang;Jiang, Zhong-Xing*
通讯作者:
Jiang, Zhong-Xing
作者机构:
[Jiang, Zhong-Xing; Lv, Xiaoyan; Yang, Zhigang] Wuhan Univ, Sch Pharmaceut Sci, Hubei Prov Engn & Technol Res Ctr Fluorinated Pha, Wuhan 430071, Hubei, Peoples R China.
[Zheng, Xing] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.
通讯机构:
[Jiang, Zhong-Xing] Wuhan Univ, Sch Pharmaceut Sci, Hubei Prov Engn & Technol Res Ctr Fluorinated Pha, Wuhan 430071, Hubei, Peoples R China.
语种:
英文
期刊:
Organic and Biomolecular Chemistry
ISSN:
1477-0520
年:
2018
卷:
16
期:
44
页码:
8537-8545
基金类别:
National Key R&D Program of China [2016YFC1304704]; National Natural Science Foundation of China [21402144, 21572168, 81625011]
机构署名:
本校为其他机构
院系归属:
药学与生物科学学院
摘要:
Dual-functionalization of monodisperse oligoethylene glycols, especially hetero-functionalization, provides a series of highly valuable intermediates for life and materials sciences. However, the existing methods for the preparation of these compounds suffer excessive protecting and activating group manipulation as well as tedious purification. Here, a one-pot dual-substitution strategy with macrocyclic sulfates of polyethylene glycols as the key intermediates was developed for the convenient and scalable preparation of a series of homo-functionalized and hetero-functionalized oligoethylene glycols in just 1 step. A high synthetic efficacy was achieved by avoiding the protecting and activating group manipulation and the intermediate purification.<br/> &copy;The Royal Society of Chemistry.

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