Adiponectin and the risk of gastrointestinal cancers in East Asians: Mendelian randomization analysis

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成果类型：

期刊论文

作者：

Jiang, Hua;Hu, Daojun;Wang, Jun;Zhang, Bo;He, Chiyi;...

通讯作者：

He, CY;Ning, JY

作者机构：

[He, Chiyi; He, CY; Jiang, Hua] Wannan Med Coll, Dept Gastroenterol, Affiliated Hosp 1, Wuhu City 241001, Anhui, Peoples R China.

[Zhang, Bo; Hu, Daojun; Wang, Jun] Shanghai Jiao Tong Univ, Dept Clin Lab, Xinhua Hosp, Sch Med, Shanghai, Peoples R China.

[Ning, Jiyu; Ning, JY] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, 69 Chuanshan Rd, Hengyang City 421001, Hunan, Peoples R China.

通讯机构：

[Ning, JY ] U

[He, CY ] W

Wannan Med Coll, Dept Gastroenterol, Affiliated Hosp 1, Wuhu City 241001, Anhui, Peoples R China.

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, 69 Chuanshan Rd, Hengyang City 421001, Hunan, Peoples R China.

语种：

英文

关键词：

adiponectin;East Asian;gastrointestinal cancer;Mendelian randomization

期刊：

Cancer Medicine

ISSN：

2045-7634

年：

2022

卷：

期：

页码：

2397-2404

DOI：

10.1002/cam4.4735

机构署名：

本校为通讯机构

摘要：

Background: Adiponectin is an important adipocytokine and has been associated with the risks of gastrointestinal cancers (GICs). Mendelian randomization (MR) analysis is needed to assess the causal relationships between adiponectin and GICs. Methods: We retrieved the summary data of genome-wide association studies for adiponectin and six types of GICs in East Asians. A series of quality control steps were performed to select the eligible genetic instrumental tools. Horizontal pleiotropy and between-SNP heterogeneity were tested to choose the pr...

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Adiponectin and the risk of gastrointestinal cancers in East Asians: Mendelian randomization analysis

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