miR-193b acts as a cisplatin sensitizer via the caspase-3-dependent pathway in HCC chemotherapy

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成果类型：

期刊论文

作者：

Yin, Wenjun;Nie, Yuehua;Zhang, Zhiwei;Xie, Liming;He, Xiusheng*

通讯作者：

He, Xiusheng

作者机构：

[Zhang, Zhiwei; He, Xiusheng; Yin, Wenjun] Univ Southern China, Canc Res Inst, Univ Key Lab Canc Cellular & Mol Pathol Hunan Pro, Coll Med, Hengyang 421001, Hunan, Peoples R China.

[Nie, Yuehua] Univ South China, Affiliated Hosp 1, Dept Radiat Oncol, Hengyang 421001, Hunan, Peoples R China.

[Xie, Liming] Univ South China, Affiliated Hosp 1, Dept Chemotherapy Oncol, Hengyang 421001, Hunan, Peoples R China.

[He, Xiusheng] Univ Southern China, Canc Res Inst, Univ Key Lab Canc Cellular & Mol Pathol Hunan Pro, Coll Med, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[He, Xiusheng] U

Univ Southern China, Canc Res Inst, Univ Key Lab Canc Cellular & Mol Pathol Hunan Pro, Coll Med, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

hepatocellular carcinoma;miR-193b;Mcl-1;cisplatin;apoptosis;caspase-3

期刊：

ONCOLOGY REPORTS

ISSN：

1021-335X

年：

2015

卷：

期：

页码：

368-374

DOI：

10.3892/or.2015.3996

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81172575]; Hunan Provincial Natural Science Committee; Hengyang City Government Unification Foundation of China [12JJ9033]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [13JJ3079]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Mounting evidence suggests that microRNAs (miRNAs) play important roles in the development of cancer by targeting expression of tumor-related genes. In the present study, downregulation of miR-193b was observed in hepatocellular carcinoma (HCC) tissues and HCC cell lines by quantitative RT-PCR analyses, suggesting that miR-193b is a tumor-suppressor in HCC. More importantly, miR-193b significantly enhanced the cytotoxicity of cisplatin in HepG2 cells by targeting Mc1-1. Knockdown of the Mc1-1 gene by specific siRNA exhibited a function similar to miR-193b on sensitizing HepG2 cells to cisplati...

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miR-193b acts as a cisplatin sensitizer via the caspase-3-dependent pathway in HCC chemotherapy

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