Nucleolin protects against doxorubicin-induced cardiotoxicity via upregulating microRNA-21

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成果类型：

期刊论文

作者：

Sun, Hui;Tong, Zhongyi;Fang, Yeqing;Jiang, Bimei*;Liang, Pengfei;...

通讯作者：

Jiang, Bimei

作者机构：

[Xiao, Xianzhong; Li, Yuanbin; Tong, Zhongyi; Sun, Hui; Jiang, Bimei; Tang, Yuting] Cent S Univ, Dept Pathophysiol, Sepsis Translat Med Key Lab Hunan Prov, Xiangya Sch Med, Changsha, Hunan, Peoples R China.

[Sun, Hui] Univ South China, Inst Cardiovasc Dis, Dept Pathophysiol, Hengyang, Hunan, Peoples R China.

[Sun, Hui] Univ South China, Key Lab Arteriosclerol Hunan Prov, Hengyang, Hunan, Peoples R China.

[Tong, Zhongyi] Cent S Univ, Xiangya Hosp 2, Dept Pathol, Changsha, Hunan, Peoples R China.

[Fang, Yeqing] Shenzhen Nanshan Peoples Hosp, Dept Cardiol, Shenzhen, Guangdong, Peoples R China.

通讯机构：

[Jiang, Bimei] C

Cent S Univ, Xiangya Sch Med, Dept Pathophysiol, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

cardiotoxicity;doxorubicin (DOX);microRNA-21 (miRNA-21);nucleolin;transgenic (TG) mice.

期刊：

JOURNAL OF CELLULAR PHYSIOLOGY

ISSN：

0021-9541

年：

2018

卷：

233

期：

页码：

9516-9525

DOI：

10.1002/jcp.26854

基金类别：

Province Natural Science Foundation of Hunan [2018JJ2547]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81220279, 81370252, 81770306, 81471868]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Nucleolin is a multifunctional protein and participates in many important biological processes. Our previous study found that nucleolin protects the heart against myocardial ischemia–reperfusion injury. In this study, we aimed to investigate the role of nucleolin in doxorubicin (DOX)‐induced cardiotoxicity. The expression pattern of nucleolin in hearts subjected to DOX injury was investigated, and we found that administration of DOX induced nucleolin expression significantly in vivo and in vitro. Gene transfection and RNA interference approac...

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Nucleolin protects against doxorubicin-induced cardiotoxicity via upregulating microRNA-21

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