Characterization and Mechanism of Linearized-Microcystinase Involved in Bacterial Degradation of Microcystins

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wei, Jia;Huang, Feiyu;Feng, Hai;Massey, Isaac Yaw;Clara, Tezi;...

通讯作者：

Yang, F.

作者机构：

[Wei, Jia; Massey, Isaac Yaw; Huang, Feiyu; Feng, Hai; Clara, Tezi; Yang, Fei; Luo, Jiayou] Cent South Univ, Xiangya Sch Publ Hlth, Hunan Prov Key Lab Clin Epidemiol, Changsha, Peoples R China.

[Long, Dingxin; Yang, Fei; Cao, Yi] Univ South China, Sch Publ Hlth, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haz, Hengyang, Peoples R China.

[Yang, Fei] Southeast Univ, Key Lab Environm Med Engn, Minist Educ, Sch Publ Hlth, Nanjing, Peoples R China.

通讯机构：

[Yang, F.] H

[Yang, F.] K

Hunan Provincial Key Laboratory of Clinical Epidemiology, China

Key Laboratory of Environmental Medicine Engineering, China

Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, China

语种：

英文

关键词：

biodegradation;homology modeling;linearized-microcystinase;microcystins;molecular docking

期刊：

Frontiers in Microbiology

ISSN：

1664-302X

年：

2021

卷：

页码：

646084

DOI：

10.3389/fmicb.2021.646084

基金类别：

This work was supported by the Hunan Province Excellent Youth Fund (2020JJ3053), Hunan Province Key Research and Development Projects (2019SK2041), and the National Natural Science Foundation (81773393).

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

Microcystins (MCs) are extremely hazardous to the ecological environment and public health. How to control and remove MCs is an unsolved problem all over the world. Some microbes and their enzymes are thought to be effective in degrading MCs. Microcystinase can linearize microcystin-leucine-arginine (MC-LR) via a specific locus. However, linearized MC-LR is also very toxic and needs to be removed. How linearized MC-LR was metabolized by linearized-microcystinase, especially how linearized-microcystinase binds to linearized MC-LR, has not been defined. A combination of in vitro experiments and ...

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Characterization and Mechanism of Linearized-Microcystinase Involved in Bacterial Degradation of Microcystins

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