Oxidized low-density lipoprotein attenuated desmoglein 1 and desmocollin 2 expression via LOX-1/Ca2+/PKC-β signal in human umbilical vein endothelial cells

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成果类型：

期刊论文

作者：

Li, Yuan-Bin;Zhang, Qing-Hai;Chen, Zhuang;He, Zhi-Jun;Yi, Guang-Hui*

通讯作者：

Yi, Guang-Hui

作者机构：

[Chen, Zhuang; Li, Yuan-Bin; He, Zhi-Jun] Hunan Tradit Chinese Med Coll, Dept Basic Med, Zhuzhou 412000, Hunan, Peoples R China.

[Zhang, Qing-Hai] Univ South China, Clin Res Inst, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.

[Yi, Guang-Hui] Univ South China, Inst Cardiovasc Dis, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Yi, Guang-Hui] U

Univ South China, Inst Cardiovasc Dis, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

DSC2;DSG1;Endothelium permeability;LOX-1;Ox-LDL;PKC

期刊：

Biochemical and Biophysical Research Communications

ISSN：

0006-291X

年：

2015

卷：

468

期：

1-2

页码：

380-386

DOI：

10.1016/j.bbrc.2015.10.079

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81270360, 31400652]; Scientific Research Fund of Hunan Provincial Education DepartmentHunan Provincial Education Department [13C838, 15C1073]

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

Numerous studies have reported the presence of oxidized LDL (ox-LDL) and expression of its lectin-like receptor, LOX-1, have been shown in atherosclerotic regions. The present study aims to investigate the effects of ox-LDL on expression of desmoglein 1 (DSG1) and desmocollin 2 (DSC2) in endothelial cells, and to explore the role of LOX-1 mediated signal in the permeability injury associated with DSG1 and DSC2 disruption induced by oxidized lipoprotein. RT-PCR and Western blotting were applied to determine the mRNA and protein expression levels...

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Oxidized low-density lipoprotein attenuated desmoglein 1 and desmocollin 2 expression via LOX-1/Ca2+/PKC-β signal in human umbilical vein endothelial cells

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