Pyroptosis, a target for cancer treatment?

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Huang, Ying;Wang, Jian-Wei;Huang, Jiao;Tang, Lu;Xu, Yun-Hua;...

通讯作者：

Tang, Jie;Wang, Guo

作者机构：

[Wang, Guo; Huang, Ying; Tang, Jie; Tang, J] Cent South Univ, Xiangya Hosp, Dept Clin Pharmacol, 87 Xiangya Rd, Changsha 410008, Peoples R China.

[Wang, Guo; Huang, Ying; Tang, Jie; Tang, J] Cent South Univ, Inst Clin Pharmacol, Hunan Key Lab Pharmacogenet, 110 Xiangya Rd, Changsha 410078, Peoples R China.

[Wang, Guo; Huang, Ying; Tang, Jie; Tang, J] Minist Educ, Engn Res Ctr Appl Technol Pharmacogen, 110 Xiangya Rd, Changsha 410078, Peoples R China.

[Wang, Guo; Huang, Ying; Tang, Jie; Tang, J] Natl Clin Res Ctr Geriatr Disorders, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

[Huang, Jiao] Guangdong Xiangxue Life Sci Ltd, 2 Jinfengyuan Rd,Sci Pk, Guangzhou 510530, Guangdong, Peoples R China.

通讯机构：

[Tang, J; Wang, G] C

[Tang, J; Wang, G] M

[Tang, J; Wang, G] N

Cent South Univ, Xiangya Hosp, Dept Clin Pharmacol, 87 Xiangya Rd, Changsha 410008, Peoples R China.

Cent South Univ, Inst Clin Pharmacol, Hunan Key Lab Pharmacogenet, 110 Xiangya Rd, Changsha 410078, Peoples R China.

语种：

英文

关键词：

Pyroptosis;Immunity;Cancer;Chemotherapy sensitivity;Cancer treatment

期刊：

Apoptosis

ISSN：

1360-8185

年：

2022

卷：

期：

1-2

页码：

1-13

DOI：

10.1007/s10495-021-01703-y

基金类别：

High-level hospital fosters grant from Fujian Provincial Hospital (No. 2019HSJJ06).

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Pyroptosis is a newly discovered form of programmed cell death mediated by the gasdermin protein, that is accompanied by inflammation and immune response. A growing body of evidence suggests that pyroptosis is closely related to cancer, and it is becoming a new cancer research topic. Studies have suggested that different cancer cells activate pyroptosis in different ways and that the effects of pyroptosis vary in different cancer backgrounds. In this article, we briefly introduce the definition, characteristics, and activation pathways of pyroptosis. Then we review the complex effects of pyrop...

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