Reciprocal Regulation Between Forkhead Box M1/NF‐κB and Methionine Adenosyltransferase 1A Drives Liver Cancer

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成果类型：

期刊论文

作者：

Li, Yuan;Lu, Liqing;Tu, Jian;Zhang, Jing;Xiong, Ting;...

通讯作者：

Liu, Ting;Lu, Shelly C.;Yang, Heping

作者机构：

[Li, Tony W. H.; Lu, Shelly C.; Wang, Jiaohong; Fan, Wei; Li, Yuan; Seki, Ekihiro; Zhang, Jing; Xiong, Ting; Tu, Jian; Lu, Liqing; Yang, Heping; Peng, Hui] Cedars Sinai Med Ctr, Div Digest & Liver Dis, Los Angeles, CA 90048 USA.

[Li, Yuan; Liu, Ting] Cent South Univ, Xiangya Hosp, Dept Gastroenterol, 78 Xiangya Rd, Changsha 410083, Hunan, Peoples R China.

[Xiong, Ting; Lu, Liqing; Chen, Yongheng; Liu, Ting] Cent South Univ, Xiangya Hosp, Chinese Minist Hlth, Key Lab Canc Prote, Changsha, Peoples R China.

[Tu, Jian] Univ South China, Inst Pharm & Pharmacol, Hengyang, Peoples R China.

[Zhang, Jing] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Oncol, Wuhan, Peoples R China.

通讯机构：

[Liu, Ting; Lu, Shelly C.; Yang, Heping] C

Cent South Univ, Xiangya Hosp, Dept Gastroenterol, 78 Xiangya Rd, Changsha 410083, Hunan, Peoples R China.

Cedars Sinai Med Ctr, Dept Med, Div Digest & Liver Dis, Davis Bldg,Room 2097,8700 Beverly Blvd, Los Angeles, CA 90048 USA.

Cedars Sinai Med Ctr, Dept Med, Div Digest & Liver Dis, Davis Bldg,Room 2094B,8700 Beverly Blvd, Los Angeles, CA 90048 USA.

语种：

英文

关键词：

FDI-6;FOX-binding site;Hepatocellular carcinoma;TO901317;cholangiocarcinoma

期刊：

Hepatology

ISSN：

0270-9139

年：

2020

卷：

期：

页码：

1682-1700

DOI：

10.1002/hep.31196

基金类别：

NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01CA172086, P01CA233452]; Plan Nacional of I+D [SAF2017-88041-R]

机构署名：

本校为其他机构

院系归属：

医学院

药学与生物科学学院

摘要：

Background and Aims Forkhead box M1 (FOXM1) and nuclear factor kappa B (NF‐ĸB) are oncogenic drivers in liver cancer that positively regulate each other. We showed that methionine adenosyltransferase 1A (MAT1A) is a tumor suppressor in the liver and inhibits NF‐ĸB activity. Here, we examined the interplay between FOXM1/NF‐κB and MAT1A in liver cancer. Approach and Results We examined gene and protein expression, effects on promoter activities and binding of proteins to promoter regions, as well as effects of FOXM1 inhibitors T090...

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Reciprocal Regulation Between Forkhead Box M1/NF‐κB and Methionine Adenosyltransferase 1A Drives Liver Cancer

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