Reciprocal Regulation Between Forkhead Box M1/NF‐κB and Methionine Adenosyltransferase 1A Drives Liver Cancer

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成果类型：

期刊论文

作者：

Li, Yuan;Lu, Liqing;Tu, Jian;Zhang, Jing;Xiong, Ting;...

通讯作者：

Liu, Ting;Lu, Shelly C.;Yang, Heping

作者机构：

[Li, Tony W. H.; Lu, Shelly C.; Wang, Jiaohong; Fan, Wei; Li, Yuan; Seki, Ekihiro; Zhang, Jing; Xiong, Ting; Tu, Jian; Lu, Liqing; Yang, Heping; Peng, Hui] Cedars Sinai Med Ctr, Div Digest & Liver Dis, Los Angeles, CA 90048 USA.

[Li, Yuan; Liu, Ting] Cent South Univ, Xiangya Hosp, Dept Gastroenterol, 78 Xiangya Rd, Changsha 410083, Hunan, Peoples R China.

[Xiong, Ting; Lu, Liqing; Chen, Yongheng; Liu, Ting] Cent South Univ, Xiangya Hosp, Chinese Minist Hlth, Key Lab Canc Prote, Changsha, Peoples R China.

[Tu, Jian] Univ South China, Inst Pharm & Pharmacol, Hengyang, Peoples R China.

[Zhang, Jing] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Oncol, Wuhan, Peoples R China.

通讯机构：

[Liu, Ting; Lu, Shelly C.; Yang, Heping] C

Cent South Univ, Xiangya Hosp, Dept Gastroenterol, 78 Xiangya Rd, Changsha 410083, Hunan, Peoples R China.

Cedars Sinai Med Ctr, Dept Med, Div Digest & Liver Dis, Davis Bldg,Room 2097,8700 Beverly Blvd, Los Angeles, CA 90048 USA.

Cedars Sinai Med Ctr, Dept Med, Div Digest & Liver Dis, Davis Bldg,Room 2094B,8700 Beverly Blvd, Los Angeles, CA 90048 USA.

语种：

英文

关键词：

FDI-6;FOX-binding site;Hepatocellular carcinoma;TO901317;cholangiocarcinoma

期刊：

Hepatology

ISSN：

0270-9139

年：

2020

卷：

期：

页码：

1682-1700

DOI：

10.1002/hep.31196

基金类别：

NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01CA172086, P01CA233452]; Plan Nacional of I+D [SAF2017-88041-R]

机构署名：

本校为其他机构

院系归属：

医学院

药学与生物科学学院

摘要：

Background and Aims: Forkhead box M1 (FOXM1) and nuclear factor kappa B (NF-ĸB) are oncogenic drivers in liver cancer that positively regulate each other. We showed that methionine adenosyltransferase 1A (MAT1A) is a tumor suppressor in the liver and inhibits NF-ĸB activity. Here, we examined the interplay between FOXM1/NF-κB and MAT1A in liver cancer. Approach and Results: We examined gene and protein expression, effects on promoter activities and binding of proteins to promoter regions, as well as effects of FOXM1 inhibitors T0901317 (T0) ...

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Reciprocal Regulation Between Forkhead Box M1/NF‐κB and Methionine Adenosyltransferase 1A Drives Liver Cancer

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