Chronic Exposure to Environmentally Relevant Concentrations of Microcystin-Leucine Arginine Causes Lung Barrier Damage through PP2A Activity Inhibition and Claudin1 Ubiquitination

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liu, Haohao;Zeng, Xin;Wang, Yueqin;Losiewicz, Michael D.;Chen, Xinghai;...

通讯作者：

Fei Yang<&wdkj&>Huizhen Zhang

作者机构：

[Liu, Haohao; Wang, Yongshui; Guo, Xing; Zhang, Huizhen; Zeng, Xin; Du, Xingde; Yuan, Shumeng; Wang, Yueqin; Zhang, Bingyu] Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R China.

[Yang, Fei] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang 421001, Hunan, Peoples R China.

[Yang, Fei] Cent South Univ, Xiangya Sch Publ Hlth, Hunan Prov Key Lab Clin Epidemiol, Changsha 410008, Hunan, Peoples R China.

[Chen, Xinghai; Losiewicz, Michael D.] St Marys Univ, Dept Chem & Biochem, San Antonio, TX 78228 USA.

通讯机构：

[Fei Yang] H

[Huizhen Zhang] C

Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang421001, Hunan, China<&wdkj&>Hunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, Changsha410008, Hunan, China<&wdkj&>College of Public Health, Zhengzhou University, Zhengzhou450001, Henan, China

语种：

英文

关键词：

MC-LR;PP2A;ubiquitination;tight junction;pneumonia;lung barrier

期刊：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ISSN：

0021-8561

年：

2022

卷：

期：

页码：

10907-10918

DOI：

10.1021/acs.jafc.2c05207

基金类别：

National Natural Science Foundation of China [82073512, 81773384, 81773393]; Key Research and Development Projects in Hunan Province [2022SK2089, 2019SK2041]; Hunan Province Excellent Youth Fund [2020JJ3053]; Huxiang Youth Talent Program [2021RC3107]; Scientific Research Start-up Fund of University of South China [201RGC008]; Center for Modern Analysis and Gene Sequencing, Zhengzhou University

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

Microcystin-leucine arginine (MC-LR), ubiquitous in water and food, is a threat to public health. In the present study, after C57BL/6J mice were fed with environmental concentrations of MC-LR (0, 1, 30, 60, 90, and 120 μg/L) for 6, 9, and 12 months, it was found that MC-LR could enter into mouse lung tissues and cause microstructural damage, as shown by western blotting and HE staining. Electron microscopy examination showed that MC-LR could damage the lung barrier by disruption of the tight junctions, which was confirmed by the decreased expr...

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Chronic Exposure to Environmentally Relevant Concentrations of Microcystin-Leucine Arginine Causes Lung Barrier Damage through PP2A Activity Inhibition and Claudin1 Ubiquitination

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