TP53 somatic mutations are associated with poor survival in non-small cell lung cancer patients who undergo immunotherapy

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成果类型：

期刊论文

作者：

Zhao, Liqin;Qu, Xiaofei;Wu, Zhenhua;Li, Yuehua;Zhang, Xiaowei*;...

通讯作者：

Zhang, Xiaowei;Guo, WeiJian

作者机构：

[Zhao, Liqin; Zhang, Xiaowei; Guo, WeiJian; Wu, Zhenhua] Fudan Univ, Dept Med Oncol, Shanghai Canc Ctr, Shanghai, Peoples R China.

[Qu, Xiaofei; Zhao, Liqin; Zhang, Xiaowei; Guo, WeiJian; Wu, Zhenhua] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China.

[Qu, Xiaofei] Fudan Univ, Canc Inst, Shanghai Canc Ctr, Shanghai, Peoples R China.

[Li, Yuehua] Univ South China, Dept Med Oncol, Affiliated Hosp 1, Hengyang, Hunan, Peoples R China.

通讯机构：

[Zhang, XW; Guo, WJ] F

Fudan Univ, Dept Med Oncol, Shanghai Canc Ctr, Shanghai, Peoples R China.

Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China.

语种：

英文

关键词：

TP53;immunotherapy;non-small cell lung cancer;somatic mutation;tumor mutation burden

期刊：

AGING-US

ISSN：

1945-4589

年：

2020

卷：

期：

页码：

14556-14568

DOI：

10.18632/aging.103502

基金类别：

This work was financially supported by the Natural Science Foundation of China (Grant No. 81871948).

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

In this study, we investigated the association between TP53 somatic mutations and immunotherapeutic outcomes in non-small cell lung cancer (NSCLC) patients. Kaplan-Meier survival curve analysis of the MSK-IMPACT cohort of 350 NSCLC patients shows that overall survival (OS) is significantly lower for patients with truncating TP53 mutations than those with wild-type TP53 (OS: 9 months vs. 14 months; P=0.019). Multivariate analysis shows that truncating TP53 mutations are an independent predictor of immunotherapeutic outcomes. Moreover, among NSCLC patients with lower tumor mutation burden (TMB),...

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TP53 somatic mutations are associated with poor survival in non-small cell lung cancer patients who undergo immunotherapy

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